Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.

Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.
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DOI:
10.1002/alz.12221
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发表时间:
2021-04
期刊:
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子:
--
通讯作者:
Wardlaw JM
Wardlaw JM
中科院分区:
其他
文献类型:
--
作者:
Hamilton OKL;Backhouse EV;Janssen E;Jochems ACC;Maher C;Ritakari TE;Stevenson AJ;Xia L;Deary IJ;Wardlaw JM

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本文是一个更新的建议,与散发性脑小血管病(SVD)相关的认知障碍的特征。我们提出了一系列关于SVD相关认知障碍的性质的问题,并根据对69项研究的已发表数据的全面综述和荟萃分析提供了答案。虽然SVD被认为主要影响执行功能和处理速度,但我们假设SVD影响认知能力的所有主要领域。我们还确定低教育水平是一个潜在的可改变的风险因素,为SVD相关的认知障碍。因此,我们建议在临床和研究环境中使用全面的认知评估和教育水平的测量,并为未来的研究提出了几点建议。
This paper is a proposal for an update on the characterisation of cognitive impairments associated with sporadic cerebral small vessel disease (SVD). We pose a series of questions about the nature of SVD-related cognitive impairments and provide answers based on a comprehensive review and meta-analysis of published data from 69 studies. Although SVD is thought primarily to affect executive function and processing speed, we hypothesise that SVD affects all major domains of cognitive ability. We also identify low levels of education as a potentially modifiable risk factor for SVD-related cognitive impairment. Therefore, we propose the use of comprehensive cognitive assessments and the measurement of educational level both in clinics and research settings, and suggest several recommendations for future research.
微出血和无症状脑梗塞与晚期脑室周围白质疏松症患者的认知功能障碍存在不同的相关性。
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