The Effect of Vitamin A on Fracture Risk: A Meta-Analysis of Cohort Studies.
The Effect of Vitamin A on Fracture Risk: A Meta-Analysis of Cohort Studies.
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维生素 A 对骨折风险的影响：队列研究的荟萃分析
DOI：
10.3390/ijerph14091043
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发表时间：
2017-09-10
影响因子：
--
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Zhang X;Zhang R;Moore JB;Wang Y;Yan H;Wu Y;Tan A;Fu J;Shen Z;Qin G;Li R;Chen G
这项荟萃分析评估了膳食摄入量和血液中维生素A（总维生素A、视黄醇或β-胡萝卜素）水平对髋部骨折和髋部骨折风险的影响。通过在多个数据库中搜索英语文献，选择2017年7月之前发表的队列研究。采用相对危险度（RR）和相应的95%置信区间（CI）来评价风险。异质性采用卡方检验和i2检验。并进行敏感性分析和发表偏倚。对于视黄醇摄入量与骨折总风险之间的关系，我们按性别、地区、病例确定、教育水平、绝经年龄和维生素D摄入量进行了亚组分析。采用R软件完成所有统计分析。共有319077名年龄在20岁以上的参与者被纳入研究。较高的膳食摄入视黄醇和总维生素A可能会略微降低总骨折风险（RR， 95% CI分别为0.95（0.91,1.00）和0.94(0.88,0.99)），并增加髋部骨折风险（RR， 95% CI分别为1.40（1.02,1.91）和1.29(1.06,1.57)）。较低的血液视黄醇水平可能会略微增加骨折的总风险（RR, 95% CI: 1.11(0.94, 1.30)）和髋部骨折的风险（RR, 95% CI: 1.27(1.05, 1.53)）。此外，较高的β-胡萝卜素摄入量与全骨折风险增加呈弱相关（RR, 95% CI: 1.07(0.97, 1.17)）。我们的数据表明，维生素A的摄入量和水平可能会对全骨折和髋部骨折的风险产生不同的影响。有必要进行临床试验以证实这些结果并评估临床适用性。
This meta-analysis evaluated the influence of dietary intake and blood level of vitamin A (total vitamin A, retinol or β-carotene) on total and hip fracture risk. Cohort studies published before July 2017 were selected through English-language literature searches in several databases. Relative risk (RR) with corresponding 95% confidence interval (CI) was used to evaluate the risk. Heterogeneity was checked by Chi-square and I2test. Sensitivity analysis and publication bias were also performed. For the association between retinol intake and total fracture risk, we performed subgroup analysis by sex, region, case ascertainment, education level, age at menopause and vitamin D intake. R software was used to complete all statistical analyses. A total of 319,077 participants over the age of 20 years were included. Higher dietary intake of retinol and total vitamin A may slightly decrease total fracture risk (RR with 95% CI: 0.95 (0.91, 1.00) and 0.94 (0.88, 0.99), respectively), and increase hip fracture risk (RR with 95% CI: 1.40 (1.02, 1.91) and 1.29 (1.06, 1.57), respectively). Lower blood level of retinol may slightly increase total fracture risk (RR with 95% CI: 1.11 (0.94, 1.30)) and hip fracture risk (RR with 95% CI: 1.27 (1.05, 1.53)). In addition, higher β-carotene intake was weakly associated with the increased risk of total fracture (RR with 95% CI: 1.07 (0.97, 1.17)). Our data suggest that vitamin A intake and level may differentially influence the risks of total and hip fractures. Clinical trials are warranted to confirm these results and assess the clinical applicability.
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影响因子：
6.2
作者：
Dai, Zhaoli;Wang, Renwei;Ang, Li-Wei;Low, Yen-Ling;Yuan, Jian-Min;Koh, Woon-Puay
通讯作者：
Koh, Woon-Puay
影响因子：
2.2
作者：
DerSimonian, Rebecca;Kacker, Raghu
通讯作者：
Kacker, Raghu
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
DOI：
10.1177/0300060516662402
发表时间：
2016-10
期刊：
The Journal of international medical research
影响因子：
--
作者：
Kim DE;Cho SH;Park HM;Chang YK
通讯作者：
Chang YK
影响因子：
64.8
作者：
BEDO, G;SANTISTEBAN, P;ARANDA, A
通讯作者：
ARANDA, A