Evaluation of reliability, validity, and responsiveness of the CDASI and the CAT-BM.
Evaluation of reliability, validity, and responsiveness of the CDASI and the CAT-BM.
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DOI：
10.1038/jid.2011.440
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发表时间：
2012-04
影响因子：
6.5
通讯作者：
Werth, Victoria P.
中科院分区：
文献类型：
--
作者：
Goreshi, Renato;Okawa, Joyce;Rose, Matt;Feng, Rui;Lee, Lela A.;Hansens, Christopher B.;Bangert, Carolyn A.;Connolly, M. Kari;Davis, Mark D.;Callen, Jeff P.;Fett, Nicole M.;Fakharzadeh, Steven S.;Clarke, Jennie T.;Werth, Victoria P.
为了正确评估皮肤皮肌炎 (DM) 的治疗，必须使用可靠、有效且对临床变化敏感的结果工具，特别是在测量疾病活动度时。本研究的目的是比较两种皮肤严重性 DM 结果指标，即皮肤疾病和活动严重程度指数 (CDASI) 和皮肤评估工具二元法 (CAT-BM)，并以医师总体评估 (PGA) 作为“金标准”。十名皮肤科医生使用 CDASI、CAT-BM 和 PGA 量表评估了 14 名 DM 患者。对每个结果工具的评估者间、评估者内的可靠性、有效性、响应性和完成时间进行了比较。对不同研究人群的反应性进行了评估，一名医生对 35 名患者进行了 110 次就诊评估。研究发现 CDASI 具有较高的评估者间和评估者内部可靠性。关于结构效度，CDASI 和 CAT-BM 都是 PGA 量表的重要预测因子。 CDASI 在所检查的三个结果工具中具有最佳的响应能力。据统计，CDASI 的完成时间比 CAT-BM 长约 1.5 分钟。患者群体较少可能会限制观察到的结果的外部有效性。 CDASI 是评估 DM 皮肤严重程度的更好临床工具。
To properly evaluate therapies for cutaneous dermatomyositis (DM), it is essential to administer an outcome instrument that is reliable, valid, and responsive to clinical change, particularly when measuring disease activity. The purpose of this study is to compare two skin-severity DM outcome measures, the Cutaneous Disease and Activity Severity Index (CDASI) and the Cutaneous Assessment Tool-Binary Method (CAT-BM), with the physician global assessment (PGA) as the ‘gold standard’. Ten dermatologists evaluated fourteen patients with DM using the CDASI, CAT-BM, and PGA scales. Inter-, intra-rater reliability, validity, responsiveness, and completion time were compared for each outcome instrument. Responsiveness was assessed from a different study population, where one physician evaluated 35 patients with 110 visits. The CDASI was found to have a higher inter- and intra-rater reliability. Regarding construct validity, both the CDASI and the CAT-BM were significant predictors of the PGA scales. The CDASI had the best responsiveness among the three outcome instruments examined. The CDASI had a statistically longer completion time than the CAT-BM by about 1.5 minutes. The small patient population may limit the external validity of the findings observed. The CDASI is a better clinical tool to assess skin severity in DM.
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DOI：
10.1111/j.1365-2133.2009.09521.x
发表时间：
2010-03
期刊：
The British journal of dermatology
影响因子：
--
作者：
Yassaee M;Fiorentino D;Okawa J;Taylor L;Coley C;Troxel AB;Werth VP
通讯作者：
Werth VP
DOI：
10.1002/art.23340
发表时间：
2008-02-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Huber, Adam M.;Dugan, Elizabeth M.;Rider, Lisa G.
通讯作者：
Rider, Lisa G.
影响因子：
6
作者：
Downing, SM
通讯作者：
Downing, SM
影响因子：
3.4
作者：
Kunz, B;Oranje, AP;Taieb, A
通讯作者：
Taieb, A
影响因子：
1.9
作者：
LANDIS, JR;KOCH, GG
通讯作者：
KOCH, GG