Modification of the cutaneous dermatomyositis disease area and severity index, an outcome instrument.
Modification of the cutaneous dermatomyositis disease area and severity index, an outcome instrument.
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DOI：
10.1111/j.1365-2133.2009.09521.x
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Werth VP
中科院分区：
文献类型：
--
作者：
Yassaee M;Fiorentino D;Okawa J;Taylor L;Coley C;Troxel AB;Werth VP
皮肤病学中经过验证的结果测量有助于标准化和改善患者护理。皮肌炎皮肤疾病严重程度的评分系统称为皮肤皮肌炎疾病面积和严重程度指数（CDASI）已经开发出来。为了简化和改进临床研究和护理工具，我们修改了CDASI并验证了新版本v2。原始CDASI有四个活动和两个损害措施。修正后的CDASI具有三种活性和两种损伤度量。对20例皮肌炎患者的皮肤病由同一位皮肤科医生用原始和改良的CDASI进行评估。实施了全球验证措施，以评估总体皮肤病状态、皮肤病活动度和皮肤损伤。根据受试者的多个观察结果调整的斯皮尔曼rho（rsp）用于确定两个版本的CDASI之间的关系及其与医生总体测量（PGM）的相关性。原始和修改后的CDASI的总分和活动和损伤子评分彼此完全相关（rsp = 0.99，1.00，1.00）。原始和改良CDASI的PGM-总体皮肤评分分别与总分（rsp = 0.72，rsp = 0.76）和活动分项评分（rsp = 0.68，rsp = 0.63）相关，但与损伤分项评分（rsp = 0.14，rsp = 0.15）无关。然而，原始和修改后的CDASI的活性（rsp = 0.76，rsp = 0.75）和损伤分项分数（rsp = 0.90，rsp = 0.90），分别与PGM活性和PGM损伤规模。修正后的CDASI与原始CDASI完全相关。它具有同样良好的并行效度与PGM-整体皮肤和PGM-活动规模。CDASI分项评分与PGM活性和PGM损伤量表具有同样好的并行效度。我们建议，皮肤病活动和损害的铂族金属应单独评估更大的特异性。改良的CDASI是一种完善的，同样有用的结局指标。
Validated outcome measures in dermatology help standardize and improve patient care. A scoring system of skin disease severity in dermatomyositis known as the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI) has been developed. To simplify and improve the tool for clinical research and care, we modified the CDASI and validated the new version, v2. The original CDASI has four activity and two damage measures. The modified CDASI has three activity and two damage measures. The skin disease of 20 patients with dermatomyositis was evaluated by the same dermatologist using both the original and the modified CDASI. Global validation measures were implemented to assess overall skin disease state, skin disease activity and skin damage. Spearman's rho (rsp), adjusted for multiple observations on subjects, was used to determine the relationship between the two versions of the CDASI and their correlation with the physician global measures (PGMs). The total score and activity and damage subscores of the original and the modified CDASI correlated perfectly with each other (rsp = 0.99, 1.00, 1.00). The PGM-overall skin scale correlated with the total scores (rsp = 0.72, rsp = 0.76) and activity subscores (rsp = 0.68, rsp = 0.63) but not with the damage subscores (rsp = 0.14, rsp = 0.15) of the original and the modified CDASI, respectively. However, the PGM-activity and PGM-damage scales correlated with the activity (rsp = 0.76, rsp = 0.75) and damage subscores (rsp = 0.90, rsp = 0.90), respectively, of the original and the modified CDASI. The modified CDASI is perfectly correlated with the original CDASI. It has equally good concurrent validity with the PGM-overall skin and PGM-activity scales. The CDASI subscores have equally good concurrent validity with the PGM-activity and PGM-damage scales. We suggest that PGMs of skin disease activity and damage should be assessed separately for greater specificity. The modified CDASI is a refined and equally as useful outcome measure.
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影响因子：
6.5
作者：
Albrecht, J;Taylor, L;Werth, VP
通讯作者：
Werth, VP
DOI：
10.1002/art.23319
发表时间：
2008-03-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Krathen, M. S.;Dunham, J.;Werth, V. P.
通讯作者：
Werth, V. P.
DOI：
10.1111/j.1365-2133.2008.08711.x
发表时间：
2008-09
期刊：
The British journal of dermatology
影响因子：
--
作者：
Klein RQ;Bangert CA;Costner M;Connolly MK;Tanikawa A;Okawa J;Rose M;Fakharzadeh SS;Fiorentino D;Lee LA;Sontheimer RD;Taylor L;Troxel AB;Werth VP
通讯作者：
Werth VP
影响因子：
--
作者：
Bonilla-Martinez, Zuleika L.;Albrecht, Joerg;Werth, Victoria P.
通讯作者：
Werth, Victoria P.
影响因子：
4.4
作者：
Singer, AJ;Thode, HC;Hollander, JE
通讯作者：
Hollander, JE