Night-shift work and incident diabetes among African-American women.

Night-shift work and incident diabetes among African-American women.
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DOI:
10.1007/s00125-014-3480-9
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发表时间:
2015-04
期刊:
影响因子:
8.2
通讯作者:
Ruiz Narvaez, Edward A.
Ruiz Narvaez, Edward A.
中科院分区:
医学1区
文献类型:
--
作者:
Vimalananda, Varsha G.;Palmer, Julie R.;Gerlovin, Hanna;Wise, Lauren A.;Rosenzweig, James L.;Rosenberg, Lynn;Ruiz Narvaez, Edward A.

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评估轮班工作与非裔美国女性 2 型糖尿病事件的关系。在黑人妇女健康研究 (BWHS) 中,这是一项正在进行的前瞻性队列研究,我们对 2005 年至 2013 年期间发生糖尿病的 28,041 名参与者进行了跟踪调查。 2005 年,他们回答了有关上夜班的问题。我们使用 Cox 比例风险模型估计了糖尿病发病的风险比 (HR) 和 95% 置信区间 (CI)。基本的多变量模型包括年龄、时间段、糖尿病家族史、教育程度和社区社会经济地位。在进一步的模型中,我们控制了生活方式因素和体重指数(BMI)。在 8 年的随访中,共有 1,786 例糖尿病病例。相对于从未上夜班的人,夜班工作 1-2 年的糖尿病 HR (95% CI) 为 1.17 (1.04, 1.31),3-9 年的糖尿病 HR 为 1.23 (1.06, 1.41),≥ 10 年的糖尿病 HR (95% CI) 为 1.42 (1.19, 1.70)(P 趋势 < 0.0001)。经过多变量调整后,夜班工作与 2 型糖尿病之间的单调正相关关系仍然存在(P 趋势 = 0.02)。这种关联并不因肥胖状况而异,但在 50 岁以下的女性中更为明显。长时间轮班工作与 2 型糖尿病风险增加相关。这种关联只能部分由生活方式因素和体重指数来解释。鉴于美国工人轮班工作的普遍性,需要更好地了解轮班工作可能影响糖尿病风险的机制。
To assess shift work in relation to incident type 2 diabetes among African American women. In the Black Women's Health Study (BWHS), an ongoing prospective cohort study, we followed 28,041 participants for incident diabetes during 2005-2013. They answered questions in 2005 about having worked the night shift. We estimated hazard ratios (HR) and 95% confidence intervals (CI) for incident diabetes using Cox proportional hazards models. The basic multivariable model included age, time period, family history of diabetes, education, and neighborhood SES. In further models, we controlled for lifestyle factors and body mass index (BMI). Over the 8 years of follow-up, there were 1,786 incident diabetes cases. Relative to never having worked the night shift, HRs (95% CI) of diabetes were 1.17 (1.04, 1.31) for 1-2 years of night shift work, 1.23 (1.06, 1.41) for 3-9 years, and 1.42 (1.19, 1.70) for ≥ 10 years (P-trend < 0.0001). The monotonic positive association between night shift work and type 2 diabetes remained after multivariable adjustment (P-trend = 0.02). The association did not vary by obesity status, but was stronger in women aged < 50 years. Long durations of shift work were associated with an increased risk of type 2 diabetes. The association was only partially explained by lifestyle factors and BMI. A better understanding of the mechanisms by which shift work may affect risk of diabetes is needed in view of the high prevalence of shift work among U.S. workers.
DOI: 10.3945/ajcn.111.013482
发表时间: 2011-07-01
影响因子: 7.1
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DOI: 10.1093/ije/dyn360
发表时间: 2009-06-01
影响因子: 7.7
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