Night-shift work and incident diabetes among African-American women.
Night-shift work and incident diabetes among African-American women.
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DOI:
10.1007/s00125-014-3480-9
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发表时间:
2015-04
期刊:
影响因子:
8.2
通讯作者:
Ruiz Narvaez, Edward A.
中科院分区:
文献类型:
--
作者:
Vimalananda, Varsha G.;Palmer, Julie R.;Gerlovin, Hanna;Wise, Lauren A.;Rosenzweig, James L.;Rosenberg, Lynn;Ruiz Narvaez, Edward A.
To assess shift work in relation to incident type 2 diabetes among African American women. In the Black Women's Health Study (BWHS), an ongoing prospective cohort study, we followed 28,041 participants for incident diabetes during 2005-2013. They answered questions in 2005 about having worked the night shift. We estimated hazard ratios (HR) and 95% confidence intervals (CI) for incident diabetes using Cox proportional hazards models. The basic multivariable model included age, time period, family history of diabetes, education, and neighborhood SES. In further models, we controlled for lifestyle factors and body mass index (BMI). Over the 8 years of follow-up, there were 1,786 incident diabetes cases. Relative to never having worked the night shift, HRs (95% CI) of diabetes were 1.17 (1.04, 1.31) for 1-2 years of night shift work, 1.23 (1.06, 1.41) for 3-9 years, and 1.42 (1.19, 1.70) for ≥ 10 years (P-trend < 0.0001). The monotonic positive association between night shift work and type 2 diabetes remained after multivariable adjustment (P-trend = 0.02). The association did not vary by obesity status, but was stronger in women aged < 50 years. Long durations of shift work were associated with an increased risk of type 2 diabetes. The association was only partially explained by lifestyle factors and BMI. A better understanding of the mechanisms by which shift work may affect risk of diabetes is needed in view of the high prevalence of shift work among U.S. workers.
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