Phenotype and function of tumor-associated neutrophils and their subsets in early-stage human lung cancer.
Phenotype and function of tumor-associated neutrophils and their subsets in early-stage human lung cancer.
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DOI：
10.1007/s00262-017-1976-0
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Eruslanov EB
中科院分区：
文献类型：
--
作者：
Eruslanov EB
中性粒细胞在多种类型的人类和小鼠肿瘤中积累，并代表肿瘤浸润骨髓细胞的很大一部分。我们目前对中性粒细胞在肿瘤发展中的作用的理解主要取决于小鼠癌症模型。然而，在肿瘤的进化、遗传多样性、免疫和炎症反应以及中性粒细胞的内在生物学方面存在着重要的物种差异，这些差异可能对小鼠与人类肿瘤中的肿瘤发展和中性粒细胞的功能产生深远的影响。迄今为止，研究癌症患者中性粒细胞的大多数实验方法仅限于检查循环血液中性粒细胞。人类肿瘤相关中性粒细胞（TAN）的表型和功能，特别是在肿瘤发展的早期阶段，尚未得到广泛研究。因此，我们工作的长期目标是表征人类 TAN 并确定它们在肿瘤发展中的具体作用。在这里，我们总结了从人类早期肺癌患者身上获得的人类 TAN 的研究结果。我们将描述在早期肺肿瘤中发现的不同 TAN 子集的表型，以及它们与 T 细胞的功能对话。
Neutrophils accumulate in many types of human and murine tumors and represent a significant portion of tumor-infiltrating myeloid cells. Our current understanding of the role of neutrophils in tumor development has depended primarily on murine models of cancer. However, there are crucial species differences in the evolution of tumors, genetic diversity, immune and inflammatory responses, and intrinsic biology of neutrophils that might have a profound impact on the tumor development and function of neutrophils in mouse versus human tumors. To date, the majority of experimental approaches to study neutrophils in cancer patients have been limited to the examination of circulating blood neutrophils. The phenotype and function of tumor-associated neutrophils (TANs) in humans, particularly in the early stages of tumor development, have not been extensively investigated. Thus, the long-term goal of our work has been to characterize human TANs and determine their specific role in tumor development. Here, we summarize our findings on human TANs obtained from human early-stage lung cancer patients. We will describe the phenotypes of different TAN subsets identified in early-stage lung tumors, as well as their functional dialog with T cells.
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影响因子：
3.7
作者：
Chacon JA;Wu RC;Sukhumalchandra P;Molldrem JJ;Sarnaik A;Pilon-Thomas S;Weber J;Hwu P;Radvanyi L
通讯作者：
Radvanyi L
DOI：
10.4049/jimmunol.1000404
发表时间：
2010-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Karulf M;Kelly A;Weinberg AD;Gold JA
通讯作者：
Gold JA
影响因子：
4.6
作者：
Granot Z;Jablonska J
通讯作者：
Jablonska J
影响因子：
16.8
作者：
Ashtekar, AR;Saha, B
通讯作者：
Saha, B
影响因子：
4.4
作者：
Abdallah, Delbert S. Abi;Egan, Charlotte E.;Denkers, Eric Y.
通讯作者：
Denkers, Eric Y.