The genus bifidobacterium: From genomics to functionality of an important component of the mammalian gut microbiota running title: Bifidobacterial adaptation to and interaction with the host.
The genus bifidobacterium: From genomics to functionality of an important component of the mammalian gut microbiota running title: Bifidobacterial adaptation to and interaction with the host.
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DOI：
10.1016/j.csbj.2021.03.006
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发表时间：
2021
影响因子：
6
通讯作者：
Ventura M
中科院分区：
文献类型：
--
作者：
Alessandri G;van Sinderen D;Ventura M
双歧杆菌属的成员是哺乳动物胃肠道的主要共生居民。由于垂直传播，双歧杆菌宿主定植在出生后立即开始，并导致宿主婴儿期阶段，在此期间双歧杆菌高度流行和丰富，然后在宿主成年期过渡到减少但稳定的丰度阶段。然而，为了到达并稳定地定殖它们的选择性生态位，即大肠，双歧杆菌必须科普沿着胃肠道（GIT）发生的大量氧化、渗透和胆汁盐/酸应激挑战。同时，双歧杆菌不仅要与无数其他肠道微生物竞争营养物质的获取，而且还需要保护它们免受细菌病毒的侵害。在这种情况下，下一代测序（NGS）技术，允许大规模的比较和功能基因组分析，有助于确定的遗传策略，双歧杆菌已经开发，以殖民，生存和适应高度竞争的哺乳动物胃肠道环境。目前的审查是旨在提供一个全面的概述有关的分子策略，biobacteria依赖于稳定和成功地殖民哺乳动物肠道。
Members of the genus Bifidobacterium are dominant and symbiotic inhabitants of the mammalian gastrointestinal tract. Being vertically transmitted, bifidobacterial host colonization commences immediately after birth and leads to a phase of host infancy during which bifidobacteria are highly prevalent and abundant to then transit to a reduced, yet stable abundance phase during host adulthood. However, in order to reach and stably colonize their elective niche, i.e. the large intestine, bifidobacteria have to cope with a multitude of oxidative, osmotic and bile salt/acid stress challenges that occur along the gastrointestinal tract (GIT). Concurrently, bifidobacteria not only have to compete with the myriad of other gut commensals for nutrient acquisition, but they also require protection against bacterial viruses. In this context, Next-Generation Sequencing (NGS) techniques, allowing large-scale comparative and functional genome analyses have helped to identify the genetic strategies that bifidobacteria have developed in order to colonize, survive and adopt to the highly competitive mammalian gastrointestinal environment. The current review is aimed at providing a comprehensive overview concerning the molecular strategies on which bifidobacteria rely to stably and successfully colonize the mammalian gut.
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影响因子：
6.4
作者：
Bottacini F;Ventura M;van Sinderen D;O'Connell Motherway M
通讯作者：
O'Connell Motherway M
影响因子：
3.7
作者：
Bottacini F;Milani C;Turroni F;Sánchez B;Foroni E;Duranti S;Serafini F;Viappiani A;Strati F;Ferrarini A;Delledonne M;Henrissat B;Coutinho P;Fitzgerald GF;Margolles A;van Sinderen D;Ventura M
通讯作者：
Ventura M
影响因子：
4.2
作者：
Alessandri, Giulia;Milani, Christian;Ventura, Marco
通讯作者：
Ventura, Marco
影响因子：
2.8
作者：
Audy, Julie;Labrie, Steve;LaPointe, Gisele
通讯作者：
LaPointe, Gisele
DOI：
10.1099/00207713-32-3-358
发表时间：
1982-01-01
期刊：
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY
影响因子：
--
作者：
BIAVATI, B;SCARDOVI, V;MOORE, WEC
通讯作者：
MOORE, WEC