Effects of hydroxyl radicals produced by a zinc phthalocyanine photosensitizer on tumor DNA
Effects of hydroxyl radicals produced by a zinc phthalocyanine photosensitizer on tumor DNA
复制标题
锌酞菁光敏剂产生的羟基自由基对肿瘤DNA的影响
DOI：
10.1016/j.dyepig.2019.107894
复制
发表时间：
2020-02
影响因子：
4.5
通讯作者：
Chen Zhuo
中科院分区：
文献类型：
--
作者：
Yan Shufeng;Guo Hanhan;Su Jianqiang;Chen Jincan;Song Xiaorong;Huang Mingdong;Zhang Juncheng;Chen Zhuo
光动力疗法（PDT）是一种新的癌症治疗方法。其机理依赖于三个要素：光敏剂、光和氧。在有氧条件下，合适波长的光激活光敏剂，导致活性氧（ROS）的形成。本文报道了酞菁锌（ZnPc）光敏剂与2,4,6-三（N， N-二甲氨基甲基）苯氧基（TAP）偶联的PDT，称为ZnPc(TAP)4，能够通过红光照射下产生的羟基自由基光降解肿瘤细胞中的DNA，从而有效消除肿瘤细胞。此外，在人乳腺腺癌细胞系MCF-7荷瘤动物模型中验证了ZnPc(TAP)4的高效抗肿瘤作用。据我们所知，这是PDT产生的羟基自由基对肿瘤细胞DNA的破坏作用首次被记录，这可能为消除肿瘤细胞DNA的抗肿瘤治疗开辟新的途径。
Photodynamic therapy (PDT) is a new therapeutic approach for cancer treatment. Its mechanism relies on three elements: photosensitizer, light and oxygen. Under aerobic conditions, a suitable wavelength of light activates the photosensitizer that results in the formation of reactive oxygen species (ROS). We herein report that PDT with a zinc phthalocyanine (ZnPc) photosensitizer coupled with 2,4,6-tris (N, N-dimethylaminomethyl) phenoxy (TAP), termed as ZnPc(TAP)4, has the ability to photodegrade DNA in tumor cells via hydroxyl radicals produced under the red light irradiation, resulting in effective elimination of tumor cells. Furthermore, the high-efficient anti-tumor effect of ZnPc(TAP)4was verified in a human breast adenocarcinoma cell line MCF-7 tumor-bearing animal model. To the best of our knowledge, this is the first time that destructive effects of hydroxyl radicals produced by PDT on DNA of tumor cells has been documented, which may open up new avenues of antitumor therapy on eliminating the DNA of tumor cells.
登录
查看更多内容
影响因子：
3.4
作者：
McGowan JV;Chung R;Maulik A;Piotrowska I;Walker JM;Yellon DM
通讯作者：
Yellon DM
影响因子：
--
作者：
D. García-Olmo;D. García-Olmo
通讯作者：
D. García-Olmo;D. García-Olmo
影响因子：
5.7
作者：
Gutteridge RE;Ndiaye MA;Liu X;Ahmad N
通讯作者：
Ahmad N
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
5.2
作者：
van Straten D;Mashayekhi V;de Bruijn HS;Oliveira S;Robinson DJ
通讯作者：
Robinson DJ