The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma.
The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma.
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DOI：
10.3389/fphar.2023.1201085
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发表时间：
2023
影响因子：
5.6
通讯作者：
Cao, Xueyuan
中科院分区：
文献类型：
--
作者：
Li, Dongming;Cao, Donghui;Cui, Yingnan;Sun, Yuanlin;Jiang, Jing;Cao, Xueyuan
肝细胞癌（Hepatocellular carcinoma，HCC）是世界上最常见的恶性肿瘤之一，具有病死率高、预后差等特点。尽管近年来肝癌的治疗策略取得了显著的突破，但肝癌的总生存率仍不令人满意。因此，肝癌的治疗仍然是一个巨大的挑战。表没食子儿茶素没食子酸酯（Epigallocatechin gallate，EGCG）是一种从茶树叶中提取的天然多酚类化合物，其抗肿瘤作用已被广泛研究。本文就表没食子儿茶素没食子酸酯在肝癌化学预防和治疗中的作用作一综述。越来越多的证据证实，EGCG通过多种生物学机制预防和抑制肝脏肿瘤的发生和发展，主要涉及肝炎病毒感染、氧化应激、增殖、侵袭、迁移、血管生成、凋亡、自噬和肿瘤代谢等。此外，EGCG增强了HCC化疗、放疗和靶向治疗的疗效和敏感性。总之，临床前研究已经证实了EGCG在各种实验模型和条件下用于HCC的化学预防和治疗的潜力。尽管如此，有迫切需要探讨的安全性和有效性的EGCG在肝癌的临床实践。
Hepatocellular carcinoma (HCC), one of the most notorious malignancies globally, has a high fatality and poor prognosis. Though remarkable breakthroughs have been made in the therapeutic strategies recently, the overall survival of HCC remains unsatisfactory. Consequently, the therapy of HCC remains a great challenge. Epigallocatechin gallate (EGCG), a natural polyphenol extracted from the leaves of the tea bush, has been extensively investigated for its antitumor effects. In this review, we summarize the previous literature to elucidate the roles of EGCG in the chemoprophylaxis and therapy of HCC. Accumulating evidence has confirmed EGCG prevents and inhibits the hepatic tumorigenesis and progression through multiple biological mechanisms, mainly involving hepatitis virus infection, oxidative stress, proliferation, invasion, migration, angiogenesis, apoptosis, autophagy, and tumor metabolism. Furthermore, EGCG enhances the efficacy and sensitivity of chemotherapy, radiotherapy, and targeted therapy in HCC. In conclusion, preclinical studies have confirmed the potential of EGCG for chemoprevention and therapy of HCC under multifarious experimental models and conditions. Nevertheless, there is an urgent need to explore the safety and efficacy of EGCG in the clinical practice of HCC.
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DOI：
10.3390/molecules27030942
发表时间：
2022-01-29
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Abudureheman B;Yu X;Fang D;Zhang H
通讯作者：
Zhang H
影响因子：
13.5
作者：
Ciesek, Sandra;von Hahn, Thomas;Steinmann, Eike
通讯作者：
Steinmann, Eike
影响因子：
5.6
作者：
Cabral-Pacheco GA;Garza-Veloz I;Castruita-De la Rosa C;Ramirez-Acuña JM;Perez-Romero BA;Guerrero-Rodriguez JF;Martinez-Avila N;Martinez-Fierro ML
通讯作者：
Martinez-Fierro ML
影响因子：
3.8
作者：
Zapf, Matthew A. C.;Kothari, Anal N.;Weber, Cynthia E.;Arffa, Matthew L.;Wai, Phillip Y.;Driver, Joseph;Gupta, Gopal N.;Kuo, Paul C.;Mi, Zhiyong
通讯作者：
Mi, Zhiyong
影响因子：
8.8
作者：
Alam, Manzar;Ali, Sabeeha;Hassan, Md Imtaiyaz
通讯作者：
Hassan, Md Imtaiyaz