A rapid rate of sex-chromosome turnover and non-random transitions in true frogs.
A rapid rate of sex-chromosome turnover and non-random transitions in true frogs.
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DOI：
10.1038/s41467-018-06517-2
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发表时间：
2018-10-05
影响因子：
16.6
通讯作者：
Perrin N
中科院分区：
文献类型：
--
作者：
Jeffries DL;Lavanchy G;Sermier R;Sredl MJ;Miura I;Borzée A;Barrow LN;Canestrelli D;Crochet PA;Dufresnes C;Fu J;Ma WJ;Garcia CM;Ghali K;Nicieza AG;O'Donnell RP;Rodrigues N;Romano A;Martínez-Solano Í;Stepanyan I;Zumbach S;Brelsford A;Perrin N
性染色体进化的经典模型预测，当重组被沿着性染色体抑制时，配子体将逐渐分化，最终成为异形体。然而，在生命之树中有许多同形性染色体的例子。这种同形性被认为是性染色体频繁转换的结果，但我们对驱动它们的力量知之甚少。在这里，我们描述了一个非常快的周转率之间的28种蛙科。转变不是随机的，而是在几条染色体上会聚，可能是由于它们所携带的基因。转换还保留了男性异配子的祖先模式，符合性染色体转换的“烫手山芋”模型，这表明非重组基因组区域中突变负荷积累的关键作用。突变负荷选择在青蛙中的重要性可能是由于它们所表现出的极端异交性，使青蛙的性染色体在出现时立即分化，并跨越它们的整个长度。促进性染色体转变的进化力量还没有得到很好的理解。在这里，Jeffries及其同事显示了真正的青蛙中非常高的性染色体更新率，这可能是由于雄性重组率低而导致的快速突变负荷积累所驱动的。
The canonical model of sex-chromosome evolution predicts that, as recombination is suppressed along sex chromosomes, gametologs will progressively differentiate, eventually becoming heteromorphic. However, there are numerous examples of homomorphic sex chromosomes across the tree of life. This homomorphy has been suggested to result from frequent sex-chromosome turnovers, yet we know little about which forces drive them. Here, we describe an extremely fast rate of turnover among 28 species of Ranidae. Transitions are not random, but converge on several chromosomes, potentially due to genes they harbour. Transitions also preserve the ancestral pattern of male heterogamety, in line with the ‘hot-potato’ model of sex-chromosome transitions, suggesting a key role for mutation-load accumulation in non-recombining genomic regions. The importance of mutation-load selection in frogs might result from the extreme heterochiasmy they exhibit, making frog sex chromosomes differentiate immediately from emergence and across their entire length. The evolutionary forces that favour transitions in sex chromosomes are not well understood. Here, Jeffries and colleagues show a very high rate of sex chromosome turnover in true frogs, which may be driven by rapid mutation-load accumulation due to the low recombination rate in males.
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影响因子：
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通讯作者：
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