Case Report: Improving Verbal Retrieval Deficits With High Definition Transcranial Direct Current Stimulation Targeting the Pre-Supplementary Motor Area in a Patient With Chronic Traumatic Brain Injury.
Case Report: Improving Verbal Retrieval Deficits With High Definition Transcranial Direct Current Stimulation Targeting the Pre-Supplementary Motor Area in a Patient With Chronic Traumatic Brain Injury.
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DOI：
10.3389/fneur.2021.678518
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发表时间：
2021
影响因子：
3.4
通讯作者：
Hart J Jr
中科院分区：
文献类型：
--
作者：
Chiang HS;Shakal S;Vanneste S;Kraut M;Hart J Jr
我们报告了一名患有认知后遗症的患者，其中包括严重创伤性脑损伤 (TBI) 后的言语检索缺陷。涉及前辅助运动区（pre-SMA）的皮质-尾状核-丘脑回路已被认为是言语检索功能的基础。我们假设针对前 SMA 的高清经颅直流电刺激 (HD-tDCS) 将选择性地调节该电路以纠正言语检索缺陷。在患者接受针对前 SMA 的 10 次每次 20 分钟的 1 mA HD-tDCS 治疗后，我们记录了言语流畅性和命名、以及涉及额叶的工作记忆和执行功能任务的显着改善。 HD-tDCS 治疗完成后，效果可持续长达 14 周。我们还证明了事件相关电位的正常化，表明对潜在神经回路的调节。我们的研究表明，特定区域的非侵入性脑刺激（例如 HD-tDCS）可以作为一种潜在的个体化治疗工具，通过诱导更持久的神经可塑性来治疗认知缺陷，即使在 TBI 的慢性阶段也是如此。
We report a patient who has cognitive sequalae including verbal retrieval deficits after severe traumatic brain injury (TBI). The cortico-caudate-thalamic circuit involving the pre-Supplementary Motor Area (pre-SMA) has been proposed to underlie verbal retrieval functions. We hypothesized that High Definition-transcranial Direct Current Stimulation (HD-tDCS) targeting the pre-SMA would selectively modulate this circuit to remediate verbal retrieval deficits. After the patient underwent 10 sessions of 20 min of 1 mA HD-tDCS targeting the pre-SMA, we documented significant improvements for verbal fluency and naming, and for working memory and executive function tasks that involve the frontal lobes. The effects persisted for up to 14 weeks after completion of HD-tDCS treatment. We also demonstrated normalization of the event-related potentials suggesting modulation of the underlying neural circuit. Our study implicates that region-specific non-invasive brain stimulation, such as HD-tDCS, serves as a potential individualized therapeutic tool to treat cognitive deficits by inducing longer-lasting neuroplasticity even in the chronic phase of TBI.
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影响因子：
4.3
作者：
Das S;Holland P;Frens MA;Donchin O
通讯作者：
Donchin O
4x1高清经颅直流电流刺激（HD-TDC）的耐受性和盲目性为两毫安。
影响因子：
7.7
作者：
Reckow J;Rahman-Filipiak A;Garcia S;Schlaefflin S;Calhoun O;DaSilva AF;Bikson M;Hampstead BM
通讯作者：
Hampstead BM
影响因子：
2.7
作者：
Mudar, Raksha A.;Chiang, Hsueh-Sheng;Maguire, Mandy J.;Spence, Jeffrey S.;Eroh, Justin;Kraut, Michael A.;Hart, John, Jr.
通讯作者：
Hart, John, Jr.
影响因子：
3.2
作者：
Li S;Zaninotto AL;Neville IS;Paiva WS;Nunn D;Fregni F
通讯作者：
Fregni F
影响因子：
3.9
作者：
Benedict, RHB;Schretlen, D;Brandt, J
通讯作者：
Brandt, J