A pilot randomized controlled trial of hearing aids to improve mood and cognition in older adults.
A pilot randomized controlled trial of hearing aids to improve mood and cognition in older adults.
复制标题
DOI：
10.1002/gps.5311
复制
发表时间：
2020-08
影响因子：
4
通讯作者：
Rutherford BR
中科院分区：
文献类型：
--
作者：
Brewster KK;Pavlicova M;Stein A;Chen M;Chen C;Brown PJ;Roose SP;Kim AH;Golub JS;Brickman A;Galatioto J;Kuhlmey M;Rutherford BR
年龄相关性听力损失(ARHL)是一种普遍存在的疾病，与抑郁和认知能力下降的风险增加有关。这项为期12周的前瞻性双盲试点随机对照试验(RCT)评估了一种新研究设计的可行性。助听器(HAS)用于患有ARHL的抑郁症老年人。N=13名年龄60岁、患有严重抑郁障碍或持续性抑郁障碍且至少有轻度听力损失(平均纯音≥为30分贝)的患者被随机分为两组，分别接受全(主动)和低放大(SHAM)，并照常接受精神治疗。使用HA的时间(以小时/天为单位)、不良事件频率、流失率和研究的维持失明是主要的结果指标。HAS的依从性很好(两组每天9小时)，不良事件和辍学率在两组之间没有差异。初步数据显示，积极与虚假在听力功能(老年人听力障碍量表[非参数效应大小(NP-ES)=.62])、抑郁症状(抑郁症状量表[NP-ES=.31])、认知(用于评估神经心理状态即时记忆的可重复电池[NP-ES=.25])和一般功能(世界卫生组织残疾评估表[NP-ES=.53])方面有不同的改善。两组都有超过50%的人正确地猜出了他们的治疗分配，这表明治疗分配没有完全隐藏。这项针对ARHL和老年抑郁症的试验性随机对照试验是可行的，并显示出临床前景，但需要改进实验治疗的盲法。更大规模的研究应该调查听力矫正是否可能是治疗老年抑郁症和认知衰退的有效预防和/或治疗策略。
Age-related hearing loss (ARHL) is a prevalent condition associated with increased risk for depression and cognitive decline. This 12-week prospective, double-blind pilot randomized controlled trial (RCT) of hearing aids (HAs) for depressed older adults with ARHL evaluated the feasibility of a novel research design. N=13 individuals aged ≥60 years with Major Depressive Disorder or Persistent Depressive Disorder and at least mild hearing loss (pure tone average ≥30dB) were randomized to receive full- (active) vs. low-amplification (sham) HAs added to psychiatric treatment as usual. Duration of HA use in hours/day, adverse events frequency, attrition rate, and maintenance of the study blinding were the primary outcome measures. Compliance with HAs was excellent (>9 hours/day for both groups) and rates of adverse events and drop-outs did not differ between groups. Preliminary data demonstrated differential improvement for active vs. sham HAs on hearing functioning (Hearing Handicap Inventory for the Elderly [nonparametric effect size (np-ES) =.62]), depressive symptoms (Inventory for Depressive Symptomatology [np-ES=.31]), cognition (Repeatable Battery for the Assessment of Neuropsychological Status Immediate Memory [np-ES=.25]), and general functioning (World Health Organization Disability Assessment Schedule [np-ES=.53]). Significantly greater than 50% of both groups correctly guessed their treatment assignment, indicating incomplete concealment of treatment allocation. This pilot RCT for ARHL and late-life depression was feasible to execute and showed clinical promise, but improved methods of blinding the experimental treatments are needed. Larger studies should investigate whether hearing remediation may be an effective preventative and/or therapeutic strategy for late-life depression and cognitive decline.
登录
查看更多内容
影响因子：
--
作者：
Lin, Frank R.;Metter, E. Jeffrey;O'Brien, Richard J.;Resnick, Susan M.;Zonderman, Alan B.;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
DOI：
10.1016/j.jagp.2018.04.003
发表时间：
2018-07
期刊：
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子：
--
作者：
Brewster KK;Ciarleglio A;Brown PJ;Chen C;Kim HO;Roose SP;Golub JS;Rutherford BR
通讯作者：
Rutherford BR
影响因子：
7.8
作者：
Choi, Janet S.;Betz, Joshua;Lin, Frank R.
通讯作者：
Lin, Frank R.
人工耳蜗之前和之后评估听力受损个体（RBANS-H）神经心理状况的可重复电池：一种前瞻性，纵向同伴研究的方案。
影响因子：
4.3
作者：
Claes AJ;Mertens G;Gilles A;Hofkens-Van den Brandt A;Fransen E;Van Rompaey V;Van de Heyning P
通讯作者：
Van de Heyning P
影响因子：
4
作者：
Acar, Baran;Yurekli, Muge Fethiye;Karasen, Riza Murat
通讯作者：
Karasen, Riza Murat