Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.
Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.
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低血清维生素D3与超重和肥胖症中代谢综合征和糖尿病的标志物的关系。
DOI：
10.1186/1475-2891-7-4
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发表时间：
2008-01-28
影响因子：
5.4
通讯作者：
Poppitt, Sally D.
中科院分区：
文献类型：
--
作者：
McGill, Anne-Thea;Stewart, Joanna M.;Lithander, Fiona E.;Strik, Caroline M.;Poppitt, Sally D.
已知低血清25羟维生素D3（维生素D3）会扰乱许多组织的细胞功能，包括内分泌胰腺，这与肥胖和II型糖尿病（TIIDM）有关。维生素D3不足与肥胖有关，无论肥胖是通过体重指数（BMI）还是腰围（腰围）来评估的。中心性肥胖，以腰围为代表，与代谢综合征（MetSyn）、胰岛素抵抗、TIIDM和动脉粥样硬化性心血管疾病（CVD）相关。我们在250名不同种族的超重和肥胖成年人的横断面样本中测试了维生素D3与脂肪量、MetSyn标记物、血红蛋白A1c （HbA1c）和MetSyn的关系。维生素D3与体重（体重）（r = -0.21, p = 0.0009）、BMI （r = -0.18, p = 0.005）、腰围（r = -0.14, p = 0.03）、体脂% （r = -0.08, p = 0.24）和糖化血红蛋白（r = -0.16, p = 0.01）呈适度负相关。分别对BMI和腰围进行的多变量回归显示，BMI每增加1 kg/m2，维生素D3减少0.74 nmol/L (p = 0.002)，腰围每增加1 cm，维生素D3减少0.29 nmol/L (p = 0.01)，每个都解释了大约3%的维生素D3在性别、年龄、种族和季节之外的变化。BMI和腰围与维生素D3之间的相似关系可能是由于BMI和腰围之间的关联，或者是巧合，维生素D3缺乏症与肥胖同时发生的不同机制。先前研究的机制包括：1)低维生素D3，可能会损害胰岛素作用、葡萄糖代谢和脂肪和瘦组织中的各种其他代谢过程；2)脂溶性维生素D3被隔离在大脂肪区，血清中含量低；3)肥胖的人可能对自己的体型很敏感，尽量减少皮肤暴露在视野和阳光下（未测试）。我们提供了支持第一种理论的证据，但没有证据支持第二种理论。在目前的研究中，血清维生素D3与体重、BMI和TIIDM标志物（腰围大、HbA1c升高）呈负相关，但与脂肪量和MetSyn本身无关。
Low serum 25 hydroxyvitamin D3 (vitamin D3) is known to perturb cellular function in many tissues, including the endocrine pancreas, which are involved in obesity and type II diabetes mellitus (TIIDM). Vitamin D3 insufficiency has been linked to obesity, whether obesity is assessed by body mass index (BMI) or waist circumference (waist). Central obesity, using waist as the surrogate, is associated with the metabolic syndrome (MetSyn), insulin resistance, TIIDM and atherosclerotic cardiovascular disease (CVD). We tested how vitamin D3 was related to measures of fat mass, MetSyn markers, haemoglobin A1c (HbA1c) and MetSyn in a cross-sectional sample of 250 overweight and obese adults of different ethnicities. There were modest inverse associations of vitamin D3 with body weight (weight) (r = -0.21, p = 0.0009), BMI (r = -0.18, p = 0.005), waist (r = -0.14, p = 0.03), [but not body fat % (r = -0.08, p = 0.24)], and HbA1c (r = -0.16, p = 0.01). Multivariable regression carried out separately for BMI and waist showed a decrease of 0.74 nmol/L (p = 0.002) in vitamin D3 per 1 kg/m2 increase in BMI and a decrease of 0.29 nmol/L (p = 0.01) per 1 cm increase in waist, with each explaining approximately 3% of the variation in vitamin D3 over and above gender, age, ethnicity and season. The similar relationships of BMI and waist with vitamin D3 may have been due to associations between BMI and waist, or coincidental, where different mechanisms relating hypovitaminosis D3 to obesity occur concurrently. Previously reviewed mechanisms include that 1) low vitamin D3, may impair insulin action, glucose metabolism and various other metabolic processes in adipose and lean tissue 2) fat soluble-vitamin D3 is sequestered in the large adipose compartment, and low in serum, 3) obese people may be sensitive about their body shape, minimising their skin exposure to view and sunlight (not tested). We showed evidence for the first theory but no evidence to support the second. In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se.
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影响因子：
16.2
作者：
Ford, ES;Ajani, UA;Liu, S
通讯作者：
Liu, S
影响因子：
4.9
作者：
Mhurchu, CN;Poppitt, SD;Rodgers, A
通讯作者：
Rodgers, A
影响因子：
5.6
作者：
Billiet, L.;Furman, C.;Rouis, M.
通讯作者：
Rouis, M.
DOI：
10.1097/mco.0b013e3282cfa32f
发表时间：
2007-09-01
影响因子：
3.1
作者：
Lytras, Aristides;Tolis, George
通讯作者：
Tolis, George
影响因子：
3.2
作者：
Need, AG;O'Loughlin, PD;Nordin, BEC
通讯作者：
Nordin, BEC