Dynamic regulation of glucocorticoid signalling in health and disease.
Dynamic regulation of glucocorticoid signalling in health and disease.
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DOI：
10.1093/rheumatology/ker215
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Lightman SL
中科院分区：
文献类型：
--
作者：
Biddie SC;Conway-Campbell BL;Lightman SL
Activation of the glucocorticoid receptor (GR) by endogenous and synthetic glucocorticoids regulates hundreds of genes to control regulatory networks in development, metabolism, cognition and inflammation. Elucidation of the mechanisms that regulate glucocorticoid action has highlighted the dynamic nature of hormone signalling and provides novel insights into genomic glucocorticoid actions. The major factors that regulate GR function include chromatin structure, epigenetics, genetic variation and the pattern of glucocorticoid hormone secretion. We review our current understanding of the mechanisms that contribute to GR signalling and how these contribute to glucocorticoid sensitivity, resistance and side effects.
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影响因子：
7.3
作者：
CHOWDREY, HS;LARSEN, PJ;LIGHTMAN, SL
通讯作者：
LIGHTMAN, SL
DOI：
10.1080/10253890802506409
发表时间：
2009-05
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Biddie SC;Hager GL
通讯作者：
Hager GL
影响因子：
16
作者：
Dechassa ML;Sabri A;Pondugula S;Kassabov SR;Chatterjee N;Kladde MP;Bartholomew B
通讯作者：
Bartholomew B
影响因子：
64.8
作者：
Chakravarti, D;LaMorte, VJ;Evans, RM
通讯作者：
Evans, RM
影响因子：
3.3
作者：
CHOVERGONZALEZ, AJ;HARBUZ, MS;LIGHTMAN, SL
通讯作者：
LIGHTMAN, SL