The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer.
The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer.
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DOI：
10.1016/bs.ai.2016.01.001
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发表时间：
2016
影响因子：
--
通讯作者：
Schreiber RD
中科院分区：
文献类型：
--
作者：
Ward JP;Gubin MM;Schreiber RD
来自小鼠癌症模型的连续实验证据和强相关的临床数据产生了癌症免疫编辑概念，该概念解释了免疫对发展中癌症的双重宿主保护和肿瘤促进作用。肿瘤特异性新抗原可以作为自发产生的对癌症的适应性免疫的靶标，从而决定发展中肿瘤的最终命运。肿瘤特异性新抗原也可以作为针对已建立肿瘤的癌症免疫疗法的最佳靶标。这些抗原来源于细胞转化过程中发生的非同义突变，并且由于它们对宿主基因组是外源的，因此不受中枢耐受性的影响。在这篇综述中，我们总结了实验证据表明，癌症新抗原的来源，自发发生的和治疗诱导的免疫反应，对癌症。我们还回顾了基因组学，生物信息学和癌症免疫治疗方面的进展，这些进展促进了新抗原的识别，并将个性化癌症免疫治疗带入临床试验，有望为癌症患者提供比当前免疫治疗更特异，更安全，更有效，甚至更普遍的治疗方法。
Definitive experimental evidence from mouse cancer models and strong correlative clinical data gave rise to the Cancer Immunoediting concept that explains the dual host-protective and tumor-promoting actions of immunity on developing cancers. Tumor-specific neoantigens can serve as targets of spontaneously arising adaptive immunity to cancer and thereby determine the ultimate fate of developing tumors. Tumor-specific neoantigens can also function as optimal targets of cancer immunotherapy against established tumors. These antigens are derived from nonsynonymous mutations that occur during cellular transformation and, because they are foreign to the host genome, are not subject to central tolerance. In this review, we summarize the experimental evidence indicating that cancer neoantigens are the source of both spontaneously occurring and therapeutically induced immune responses against cancer. We also review the advances in genomics, bioinformatics, and cancer immunotherapy that have facilitated identification of neoantigens and have moved personalized cancer immunotherapies into clinical trials, with the promise of providing more specific, safer, more effective, and perhaps even more generalizable treatments to cancer patients than current immunotherapies.
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MHC I类的性质提出了增强免疫原性的肽。
影响因子：
4.3
作者：
Calis JJ;Maybeno M;Greenbaum JA;Weiskopf D;De Silva AD;Sette A;Keşmir C;Peters B
通讯作者：
Peters B
DOI：
10.1084/jem.179.3.1005
发表时间：
1994-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bakker AB;Schreurs MW;de Boer AJ;Kawakami Y;Rosenberg SA;Adema GJ;Figdor CG
通讯作者：
Figdor CG
影响因子：
4.4
作者：
DEBACKER, O;VERHEYDEN, AM;BOON, T
通讯作者：
BOON, T
影响因子：
56.9
作者：
Altman, JD;Moss, PAH;Davis, MM
通讯作者：
Davis, MM
影响因子：
29.7
作者：
Blum JS;Wearsch PA;Cresswell P
通讯作者：
Cresswell P