Retinal ganglion cell layer thickness and volume measured by OCT changes with age, sex, and axial length in a healthy population.
Retinal ganglion cell layer thickness and volume measured by OCT changes with age, sex, and axial length in a healthy population.
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DOI：
10.1186/s12886-022-02488-7
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发表时间：
2022-06-24
影响因子：
2
通讯作者：
Lagali, Neil
中科院分区：
文献类型：
--
作者：
Al-Hawasi, Abbas;Lagali, Neil
关键词：
使用光学相干断层扫描 (OCT) 进行神经节细胞层 (GCL) 测量对于眼科医生和神经科医生都很重要，因为它们与许多眼科和神经系统疾病相关。不同的因素会影响这些测量结果，例如大脑病理、眼轴长度 (AL) 以及年龄和性别。衡量 GCL 的研究忽略了其中许多因素。本研究的目的是检查年龄、性别和 AL 对没有任何神经系统疾病的健康人群中正常视网膜 GCL 厚度和体积的影响。一项前瞻性横断面研究旨在通过 OCT 测量 GCL 厚度和总体积，并在需要时进行自动分割和手动校正。还测量了视力、AL 和自折射。使用混合线性模型来确定各种参数对 GCL 厚度和体积的影响的关联。对 60 名受试者（12-76 岁，55% 女性）的 116 只眼睛进行了检查，其中 77% 的等效球镜度为 0±±2 D，平均眼轴长度为 23.86 毫米。大约 25% 的 OCT 自动 GCL 测量需要手动校正。右眼和左眼相似解剖区域的 GCL 厚度没有差异（P > 0.05）。调整年龄和眼轴长度后，男性 GCL 体积大于女性（男性 1.13±0.07 mm3，女性 1.09±0.09 mm3；P=0.031）。男性和女性视网膜内环的 GCL 厚度存在差异（P = 0.025），但外环则没有差异（P = 0.66）。 GCL 体积随着年龄的增长而下降 (P = 0.031)，但在调整性别和眼轴长度后却没有下降 (P = 0.138)。调整年龄和性别后，GCL 体积随着眼轴长度的延长而下降（P = 0.048）。使用 OCT 测量 GCL 厚度和体积时应考虑年龄、性别和眼轴长度。应审查自动 OCT 分割以进行手动调整。
The ganglion cell layer (GCL) measurements with Optical Coherence Tomography (OCT) are important for both ophthalmologists and neurologists because of their association with many ophthalmic and neurological diseases. Different factors can affect these measurements, such as brain pathologies, ocular axial length (AL) as well as age and sex. Studies conducted to measure the GCL have overlooked many of these factors. The purpose of this study is to examine the effect of age, sex, and AL on normal retinal GCL thickness and volume in a healthy population without any neurological diseases. A prospective cross-sectional study was designed to measure GCL thickness and total volume with OCT with automated segmentation and manual correction where needed. Visual acuity, AL, and autorefraction were also measured. A mixed linear model was used to determine the association of the effect of the various parameters on the GCL thickness and volume. One hundred and sixteen eyes of 60 subjects (12–76 years of age, 55% female) were examined of which 77% had 0 ± 2 D of spherical equivalent, and mean axial length was 23.86 mm. About 25% of the OCT-automated GCL measurements required manual correction. GCL thickness did not differ in similar anatomic regions in right and left eyes (P > 0.05). GCL volume was greater in males relative to females after adjustment for age and axial length (1.13 ± 0.07 mm3 for males vs 1.09 ± 0.09 mm3 for females; P = 0.031). GCL thickness differed between males and females in the inner retinal ring (P = 0.025) but not in the outer ring (P = 0.66). GCL volume declined with age (P = 0.031) but not after adjustment for sex and axial length (P = 0.138). GCL volume declined with longer axial length after adjustment for age and sex (P = 0.048). Age, sex and axial length should be taken into consideration when measuring the GCL thickness and volume with OCT. Automated OCT segmentation should be reviewed for manual adjustments.
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作者：
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