Frontal midline theta reflects anxiety and cognitive control: meta-analytic evidence.

Frontal midline theta reflects anxiety and cognitive control: meta-analytic evidence.
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DOI:
10.1016/j.jphysparis.2014.04.003
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发表时间:
2015-02
影响因子:
--
通讯作者:
Shackman, Alexander J.
Shackman, Alexander J.
中科院分区:
其他
文献类型:
--
作者:
Cavanagh, James F.;Shackman, Alexander J.

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影像学和解剖学研究的证据表明,中扣带皮层(MCC)是处于情感和认知界面的动态枢纽。特别是,这个神经系统似乎整合了关于冲突和惩罚的信息,以便在面对行动-结果的不确定性时优化行为。在一系列的荟萃分析中,我们展示了最近的人类电生理学研究如何提供令人信服的证据,表明反映MCC活动的额中线θ信号受到焦虑的调节,并预测适应性行为调整。这些发现强调了额叶θ活动对广泛的控制操作的重要性。我们认为,额中线θ提供了一种神经生理学上合理的机制,可以最佳地调整行为以适应不确定性,这是引发焦虑和需要认知控制的情况的标志。这些观察结果促使人们对引导动机学习和行为的机制有了新的看法,并为理解MCC在气质和精神病理中的作用提供了一个框架。
Evidence from imaging and anatomical studies suggests that the midcingulate cortex (MCC) is a dynamic hub lying at the interface of affect and cognition. In particular, this neural system appears to integrate information about conflict and punishment in order to optimize behavior in the face of action-outcome uncertainty. In a series of meta-analyses, we show how recent human electrophysiological research provides compelling evidence that frontal-midline theta signals reflecting MCC activity are moderated by anxiety and predict adaptive behavioral adjustments. These findings underscore the importance of frontal theta activity to a broad spectrum of control operations. We argue that frontal-midline theta provides a neurophysiologically plausible mechanism for optimally adjusting behavior to uncertainty, a hallmark of situations that elicit anxiety and demand cognitive control. These observations compel a new perspective on the mechanisms guiding motivated learning and behavior and provide a framework for understanding the role of the MCC in temperament and psychopathology.
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