Secondhand smoke exposure and asthma outcomes among African-American and Latino children with asthma.
Secondhand smoke exposure and asthma outcomes among African-American and Latino children with asthma.
复制标题
DOI：
10.1136/thoraxjnl-2017-211383
复制
发表时间：
2018-11
期刊：
影响因子：
10
通讯作者：
Burchard EG
中科院分区：
文献类型：
--
作者：
Neophytou AM;Oh SS;White MJ;Mak ACY;Hu D;Huntsman S;Eng C;Serebrisky D;Borrell LN;Farber HJ;Meade K;Davis A;Avila PC;Thyne SM;Rodríguez-Cintrón W;Rodríguez-Santana JR;Kumar R;Brigino-Buenaventura E;Sen S;Lenoir MA;Williams LK;Benowitz NL;Balmes JR;Eisen EA;Burchard EG
二手烟（SHS）暴露与哮喘相关结果有关，但使用暴露生物标志物的定量剂量反应尚未得到广泛报道。评估少数民族儿童血浆可替宁测定的二手烟暴露与哮喘结局之间的剂量反应关系，少数民族儿童是暴露于较高水平二手烟的弱势群体，且在文献中代表性不足。我们对来自美国大陆和波多黎各的 1172 名患有哮喘的拉丁裔和非裔美国儿童进行了分析。我们使用逻辑回归来评估可替宁水平≥0.05 ng/mL与前一年哮喘加重（定义为哮喘相关住院、急诊室就诊或口服类固醇处方）和哮喘控制之间的关系。使用带有惩罚样条的广义加法逻辑模型中的连续暴露变量来评估剂量反应关系的形状。可替宁水平≥0.05 ng/mL 与 <0.05 ng/mL 相比，前一年出现哮喘恶化的比值比 (OR) 为 1.40（95% 置信区间 (CI)：1.03 – 1.89），而哮喘控制不佳的 OR 为 1.53（95% CI：1.12 – 2.13）。剂量反应关系分析表明，哮喘结果的发生几率与接触量的增加有关，即使在与轻度二硫HS暴露相关的可替宁水平下也是如此。暴露于二手烟与哮喘急性发作的几率较高有关，并且即使在低暴露水平下，哮喘控制不佳也会增加剂量反应。我们的结果支持这样的结论：二手烟暴露没有安全水平。
Secondhand smoke (SHS) exposures have been linked to asthma related outcomes but quantitative dose-responses using biomarkers of exposure have not been widely reported. Assess dose-response relationships between plasma cotinine-determined SHS exposure and asthma outcomes in minority children, a vulnerable population exposed to higher levels of SHS and underrepresented in the literature. We performed analyses in 1172 Latino and African American children with asthma from the mainland US and Puerto Rico. We used logistic regression to assess relationships of cotinine levels ≥0.05 ng/mL with asthma exacerbations (defined as asthma related hospitalizations, emergency room visits or oral steroid prescription) in the previous year and asthma control. The shape of dose-response relationships was assessed using a continuous exposure variable in generalized additive logistic models with penalized splines. The odds ratio (OR) for experiencing asthma exacerbations in the previous year for cotinine levels ≥0.05 ng/mL, compared to <0.05 ng/mL was 1.40 (95% confidence interval (CI): 1.03 – 1.89), while the OR for poor asthma control was 1.53 (95% CI: 1.12 – 2.13). Analyses for dose-response relationships indicated increasing odds of asthma outcomes related with increasing exposure, even at cotinine levels associated with light SHS exposures. Exposure to SHS was associated with higher odds of asthma exacerbations and having poorly controlled asthma with an increasing dose-response even at low levels of exposure. Our results support the conclusion that there are no safe levels of SHS exposures.
登录
查看更多内容
DOI：
10.1164/rccm.201410-1944pp
发表时间：
2015-03-01
影响因子：
24.7
作者：
Burchard, Esteban G.;Oh, Sam S.;Celedon, Juan C.
通讯作者：
Celedon, Juan C.
DOI：
10.1093/jnci/94.2.108
发表时间：
2002-01-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Benowitz, NL;Pérez-Stable, EJ;Jacob, P
通讯作者：
Jacob, P
DOI：
10.1001/archpediatrics.2012.170
发表时间：
2012-09-01
影响因子：
--
作者：
Dempsey, Delia A.;Meyers, Matthew J.;Oh, Sam S.;Nguyen, Elizabeth A.;Fuentes-Afflick, Elena;Wu, Alan H. B.;Jacob, Peyton, III;Benowitz, Neal L.
通讯作者：
Benowitz, Neal L.
影响因子：
9.6
作者：
Hankinson, John L.;Kawut, Steven M.;Barr, R. Graham
通讯作者：
Barr, R. Graham
DOI：
10.1164/ajrccm.163.2.2006009
发表时间：
2001-02-01
影响因子：
24.7
作者：
Gilliland, FD;Li, YF;Peters, JM
通讯作者：
Peters, JM