Erythropoietin protects cardiac myocytes against anthracycline-induced apoptosis.
Erythropoietin protects cardiac myocytes against anthracycline-induced apoptosis.
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促红细胞生成素可保护心肌细胞免受蒽环类药物诱导的细胞凋亡。
DOI：
10.1016/j.bbrc.2007.01.044
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发表时间：
2007
影响因子：
3.1
通讯作者：
Arcasoy,MuratO
中科院分区：
文献类型：
--
作者：
Fu,Ping;Arcasoy,MuratO
The cardiotoxic adverse effects of anthracycline antibiotics limit their therapeutic utility as essential components of chemotherapy regimens for hematologic and solid malignancies. Here we show that the hematopoietic cytokine erythropoietin attenuates doxorubicin-induced apoptosis of primary neonatal rat ventricular cardiomyocytes in a dose-dependent manner. Erythropoietin treatment induced rapid, time-dependent phosphorylation of MAP kinases (MAPK) Erk1/2 and the phosphatidylinositol 3-kinase substrate Akt. Treatment of cardiomyocytes with inhibitors of phosphatidylinositol 3-kinase (LY294002) or Akt (Akti-1/2) abolished the protective effect of erythropoietin, whereas treatment with MAPK kinase (MEK1) inhibitor U0126 did not. Erythropoietin also induced the phosphorylation of GSK-3β, a downstream target of PI3K-Akt. Because phosphorylation is known to inactivate GSK-3β, we investigated whether GSK-3β inhibition is cardioprotective. We found that GSK-3β inhibitors SB216763 or lithium chloride blocked doxorubicin-induced cardiomyocyte apoptosis in a manner similar to erythropoietin, suggesting that GSK-3β inhibition is involved in erythropoietin-mediated cardioprotection. Erythropoietin may serve as a novel cardioprotective agent against anthracycline-induced cardiotoxicity.
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DOI：
10.1210/jcem-29-6-757
发表时间：
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期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
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DOI：
10.1677/joe.0.0450459
发表时间：
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期刊：
The Journal of endocrinology
影响因子：
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作者：
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DOI：
10.1210/jcem-51-3-466
发表时间：
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期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
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影响因子：
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作者：
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