Autism-linked gene FoxP1 selectively regulates the cultural transmission of learned vocalizations.
Autism-linked gene FoxP1 selectively regulates the cultural transmission of learned vocalizations.
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自闭症相关的基因FOXP1选择性地调节了学到的发声的文化传播。
DOI：
10.1126/sciadv.abd2827
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发表时间：
2021-03
期刊：
影响因子：
13.6
通讯作者：
Roberts TF
中科院分区：
文献类型：
--
作者：
Garcia-Oscos F;Koch TMI;Pancholi H;Trusel M;Daliparthi V;Co M;Park SE;Ayhan F;Alam DH;Holdway JE;Konopka G;Roberts TF
自闭症基因FoxP1的表达中断，阻碍了幼鸟形成用于学习成年歌曲的记忆的能力。自闭症谱系障碍（ASD）的特征是社交技能和语言学习受损。对父母和其他社会模式行为方式的记忆被用来指导行为学习。自闭症相关基因如何影响观察学习和行为模仿的相互交织的方面尚不清楚。在这里，我们研究了ASD基因FOXP1的表达中断，这会导致严重的言语和语言学习障碍，影响成年和少年斑胸草雀之间的鸟鸣的文化传播。FoxP1在纹状体投射的前脑镜像神经元中广泛表达。在这个回路中，FoxP1的敲除可以阻止幼鸟形成对成年歌曲模型的记忆，但不会中断学习如何用声音模仿先前记忆的歌曲。这种选择性学习缺陷与镜像神经元中经验依赖性结构和突触可塑性的有效破坏有关。因此，FoxP1调节形成对行为的文化传播至关重要的记忆的能力。
Disrupted expression of the autism gene, FoxP1, blocks the ability of young birds to form memories used to learn their adult song. Autism spectrum disorders (ASDs) are characterized by impaired learning of social skills and language. Memories of how parents and other social models behave are used to guide behavioral learning. How ASD-linked genes affect the intertwined aspects of observational learning and behavioral imitation is not known. Here, we examine how disrupted expression of the ASD gene FOXP1, which causes severe impairments in speech and language learning, affects the cultural transmission of birdsong between adult and juvenile zebra finches. FoxP1 is widely expressed in striatal-projecting forebrain mirror neurons. Knockdown of FoxP1 in this circuit prevents juvenile birds from forming memories of an adult song model but does not interrupt learning how to vocally imitate a previously memorized song. This selective learning deficit is associated with potent disruptions to experience-dependent structural and synaptic plasticity in mirror neurons. Thus, FoxP1 regulates the ability to form memories essential to the cultural transmission of behavior.
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影响因子：
3.2
作者：
Hickok G
通讯作者：
Hickok G
影响因子：
64.8
作者：
KONISHI, M;AKUTAGAWA, E
通讯作者：
AKUTAGAWA, E
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Aronov, Dmitriy;Andalman, Aaron S.;Fee, Michale S.
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Fee, Michale S.
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Hamaguchi K;Tschida KA;Yoon I;Donald BR;Mooney R
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Mooney R
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3.3
作者：
Fee, M. S.;Goldberg, J. H.
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Goldberg, J. H.