White matter microstructure of children with sensory over-responsivity is associated with affective behavior.
White matter microstructure of children with sensory over-responsivity is associated with affective behavior.
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DOI：
10.1186/s11689-023-09513-w
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发表时间：
2024-01-02
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
--
作者：
学龄儿童感觉加工功能障碍与白色物质（WM）微结构改变有关。感觉过度反应（SOR）是SPD的一种形式，影响至少2.5%的儿童，并对学习和心理健康产生严重的有害影响。然而，SOR还没有得到很好的研究，使用微结构成像，如扩散MRI（dMRI）。由于SOR涉及对外部刺激的超敏反应，我们测试的假设，即儿童SOR需要补偿神经可塑性的形式，上级WM微观结构的完整性，以防止内化行为，留下那些与受损的WM微观结构容易躯体化和抑郁症。使用全面结构化临床评价（感觉处理三维评估）评估有神经发育问题的8-12岁儿童的SOR，并使用多壳多频带dMRI进行3 T MRI。基于道的空间统计被用来测量扩散张量成像（DTI）和神经突方向分散和密度成像（NODDI）的指标，从全球WM和十九个选定的WM道。在SOR组和有神经发育问题但没有SOR的匹配儿童中计算DTI和NODDI测量值与儿童行为评估系统第3版（BASC-3）中躯体化和情绪障碍测量值的相关性。整体WM各向异性分数（FA）在SOR组与躯体化和情绪障碍呈负相关，而非SOR组则无相关性。在SOR患儿中还观察到径向扩散率（RD）和游离水分数（FISO）与躯体化呈正相关，在大多数情况下，与情绪障碍呈正相关。这些影响在患有SOR的男孩中是显著的，而这项研究对女孩的影响力不足。最受影响的白色物质是内侧丘系和内囊感觉束，尽管在许多大脑，小脑和脑干束中观察到SOR的影响。白色物质微结构与SOR儿童的情感行为相关。在线版本包含补充材料，可通过10.1186/s11689-023-09513-w获得。
Sensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory over-responsivity (SOR), a form of SPD, affects at least 2.5% of all children and has substantial deleterious impact on learning and mental health. However, SOR has not been well studied using microstructural imaging such as diffusion MRI (dMRI). Since SOR involves hypersensitivity to external stimuli, we test the hypothesis that children with SOR require compensatory neuroplasticity in the form of superior WM microstructural integrity to protect against internalizing behavior, leaving those with impaired WM microstructure vulnerable to somatization and depression. Children ages 8–12 years old with neurodevelopmental concerns were assessed for SOR using a comprehensive structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment, and underwent 3 Tesla MRI with multishell multiband dMRI. Tract-based spatial statistics was used to measure diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics from global WM and nineteen selected WM tracts. Correlations of DTI and NODDI measures with measures of somatization and emotional disturbance from the Behavioral Assessment System for Children, 3rd edition (BASC-3), were computed in the SOR group and in matched children with neurodevelopmental concerns but not SOR. Global WM fractional anisotropy (FA) is negatively correlated with somatization and with emotional disturbance in the SOR group but not the non-SOR group. Also observed in children with SOR are positive correlations of radial diffusivity (RD) and free water fraction (FISO) with somatization and, in most cases, emotional disturbance. These effects are significant in boys with SOR, whereas the study is underpowered for girls. The most affected white matter are medial lemniscus and internal capsule sensory tracts, although effects of SOR are observed in many cerebral, cerebellar, and brainstem tracts. White matter microstructure is related to affective behavior in children with SOR. The online version contains supplementary material available at 10.1186/s11689-023-09513-w.
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DOI：
10.1016/j.jaac.2013.08.004
发表时间：
2013-11
影响因子：
13.3
作者：
Green, Shulamite A.;Rudie, Jeffrey D.;Colich, Natalie L.;Wood, Jeffrey J.;Shirinyan, David;Hernandez, Leanna;Tottenham, Nim;Dapretto, Mirella;Bookheimer, Susan Y.
通讯作者：
Bookheimer, Susan Y.
影响因子：
5.7
作者：
Bastiani M;Cottaar M;Fitzgibbon SP;Suri S;Alfaro-Almagro F;Sotiropoulos SN;Jbabdi S;Andersson JLR
通讯作者：
Andersson JLR
DOI：
10.1038/nrn.2018.1
发表时间：
2018-02-16
期刊：
Nature reviews. Neuroscience
影响因子：
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作者：
Gilmore JH;Knickmeyer RC;Gao W
通讯作者：
Gao W
影响因子：
5.7
作者：
Daducci, Alessandro;Canales-Rodriguez, Erick J.;Thiran, Jean-Philippe
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Thiran, Jean-Philippe
影响因子：
3.1
作者：
Andre, Quinn R.;Geeraert, Bryce L.;Lebel, Catherine
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Lebel, Catherine