Increased neural reactivity to emotional pictures in men with high hair testosterone concentrations
Increased neural reactivity to emotional pictures in men with high hair testosterone concentrations
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头发睾酮浓度高的男性对情绪图像的神经反应增加
DOI：
10.1093/scan/nsz067
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发表时间：
2019
影响因子：
4.2
通讯作者：
Klucken
中科院分区：
文献类型：
--
作者：
Tapia Léon;Stalder;Klucken
情绪神经回路包括杏仁核、眶额皮质（OFC）和杏仁核的活动改变，以及功能性杏仁核/前额叶耦合的减少。这种关联仅使用睾酮的急性测量进行过研究，因此对长期睾酮分泌的各自关系知之甚少。在这里，我们研究头发睾酮浓度（HTC），长期累积的睾酮水平和神经反应性的指数在情绪被动观看任务使用功能性磁共振成像（fMRI）之间的关联。46名男性在MRI中观看了阴性，阳性和中性图片。从2cm毛发段评估HTC。情绪范式引起杏仁核、脑岛和眶额皮质的神经激活。HTCs与增加的反应性负图片的大脑皮层和增加的反应性阳性图片的OFC。我们发现长期的睾丸激素水平与大脑中情绪反应的增加有关。这些结果表明，在具有高特质睾酮水平的个体中，情绪警惕性提高。
Testosterone has been linked to alterations in the activity of emotion neurocircuitry including amygdala, orbitofrontal cortex (OFC) and insula and diminished functional amygdala/prefrontal coupling. Such associations have only ever been studied using acute measures of testosterone, thus little is known about respective relationships with long-term testosterone secretion. Here, we examine associations between hair testosterone concentration (HTC), an index of long-term cumulative testosterone levels and neural reactivity during an emotional passive viewing task using functional magnetic resonance imaging (fMRI). Forty-six men viewed negative, positive and neutral pictures in the MRI. HTCs were assessed from 2 cm hair segments. The emotional paradigm elicited neural activation in the amygdala, insula and OFC. HTCs were associated with increased reactivity to negative pictures in the insula and increased reactivity to positive pictures in the OFC. We show an association of long-term testosterone levels with increased emotional reactivity in the brain. These results suggest a heightened emotional vigilance in individuals with high trait testosterone levels.
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影响因子：
5.4
作者：
M. Botvinick;T. Braver;D. Barch;C. Carter;J. Cohen
通讯作者：
M. Botvinick;T. Braver;D. Barch;C. Carter;J. Cohen
影响因子：
3.1
作者：
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通讯作者：
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
3.7
作者：
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通讯作者：
van Honk, Jack
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影响因子：
3.5
作者：
S. Anders;L. D. Hamilton;N. Watson
通讯作者：
N. Watson