Presence of sarcopenia identifies a special group of lean NAFLD in middle-aged and older people
Presence of sarcopenia identifies a special group of lean NAFLD in middle-aged and older people
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肌肉减少症的存在表明中年和老年人中存在瘦 NAFLD 的特殊群体
DOI：
10.1007/s12072-022-10439-z
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发表时间：
2022-11
影响因子：
6.6
通讯作者：
Mingfeng Xia
中科院分区：
文献类型：
--
作者：
Xiaopeng Zhu;Qingxia Huang;Shuai Ma;Lingyan Chen;Qi Wu;Li Wu;Hui Ma;Xiaoming Li;Qian Li;Qiqige Aleteng;Yu Hu;Wanyuan He;Jian Gao;Hu;ong Lin;Huiru Tang;Xin Gao;Mingfeng Xia
背景肌减少症是一种与年龄相关的肌肉质量和功能的丧失，与非酒精性脂肪性肝病（NAFLD）密切相关并常伴发。我们的目的是调查的肌肉减少NAFLD患者的临床特点，从中老年people.MethodsA共1305例NAFLD患者从上海长风研究纳入分析。根据身高调整后的上腹部骨骼肌质量（ASM/身高2）诊断肌肉减少症。我们全面分析了代谢表型，颈动脉状况，肝纤维化评分，和血清代谢profile的每个participant.ResultsAmong的中年和老年人的人口，68.1%的患者肌肉减少症和NAFLD瘦。肌肉减少症与颈动脉斑块风险增加独立相关（OR，2.22; 95%CI 1.23-4.02）和肝纤维化（OR，2.07; 95%CI 1.24-3.44），肌肉减少型瘦型NAFLD患者颈动脉斑块风险较高（p= 0.008）和肝纤维化（p= 0.001），尽管他们的BMI较低，代谢综合征和糖尿病的患病率相似。进一步的血清代谢组学检查表明，肌肉减少的瘦型NAFLD患者呈现出明显的代谢组学特征，易于颈动脉斑块和肝纤维化，血清缬氨酸、N-乙酰神经氨酰糖蛋白、乳酸、小LDL甘油三酯和VLDL 5组分上调，HDL 4组分降低。基于上述代谢产物的肌肉减少症特征评分建立，也可以预测颈动脉斑块和肝纤维化的风险增加。ConclusionThe presence of sarcopenia identifies a special subgroup of lean NAFLD with increased risk of cardiovascular diseases and liver fibrosis clinical.
BackgroundSarcopenia, the age-related loss of muscle mass and function, is closely associated and frequently concomitant with non-alcoholic fatty liver disease (NAFLD). We aimed to investigate the clinical features of the sarcopenic NAFLD patients from middle-aged and older people.MethodsA total of 1305 patients with NAFLD from the Shanghai Changfeng Study were included for analysis. Sarcopenia was diagnosed based on the height-adjusted appendicular skeletal muscle mass (ASM/height2). We comprehensively analyzed the metabolic phenotype, carotid artery condition, liver fibrosis score, and serum metabolomic profile of each participant.ResultsAmong the middle-aged and older population, 68.1% of patients with sarcopenia and NAFLD were lean. Sarcopenia was independently associated with increased risk of carotid plaque (OR, 2.22; 95%CI 1.23–4.02) and liver fibrosis (OR, 2.07; 95%CI 1.24–3.44), and the sarcopenic lean NAFLD patients were characterized by a higher risk of carotid plaque (p= 0.008) and liver fibrosis (p= 0.001) than the non-sarcopenic lean NAFLD patients, despite their lower BMI and similar prevalence of metabolic syndrome and diabetes. Further serum metabolomic examination indicated that the sarcopenic lean NAFLD patients presented a distinct metabolomic profile prone to carotid plaque and liver fibrosis, with upregulated serum valine, N-acetylneuraminyl-glycoproteins, lactic acid, small LDL triglycerides and VLDL5 components, and reduced components of HDL4. A sarcopenic characterization score based on above metabolites was established and could also predict increased risk of carotid plaque and liver fibrosis.ConclusionThe presence of sarcopenia identifies a special subgroup of lean NAFLD with increased risk of cardiovascular disease and liver fibrosis clinically.Graphical abstract
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影响因子：
7.6
作者：
Mingfeng Xia;Shuai Ma;Qingxia Huang;Hailuan Zeng;Jieyu Ge;Wenjie Xu;Qi Wu;Li Wu;Xiaoming Li;Hui Ma;Lingyan Chen;Qian Li;Qiqige Aleteng;Yu Hu;Wanyuan He;Baishen Pan;Hu;ong Lin;Yan Zheng;Sijia Wang;Huiru Tang;Xin Gao
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Mingfeng Xia;Hailuan Zeng;Sijia Wang;Huiru Tang;Xin Gao
影响因子：
6.9
作者：
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通讯作者：
Gao, Xin
DOI：
10.1161/atvbaha.116.307156
发表时间：
2016-05-01
影响因子：
8.7
作者：
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通讯作者：
Ryu, Seungho
影响因子：
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作者：
Younossi, Zobair M.;Stepanova, Maria;Henry, Linda
通讯作者：
Henry, Linda