FNDC5/irisin is not only a myokine but also an adipokine.
FNDC5/irisin is not only a myokine but also an adipokine.
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DOI：
10.1371/journal.pone.0060563
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Pardo M
中科院分区：
文献类型：
--
作者：
Roca-Rivada A;Castelao C;Senin LL;Landrove MO;Baltar J;Belén Crujeiras A;Seoane LM;Casanueva FF;Pardo M
运动对预防许多疾病有明显的有益效果。然而，许多负责运动的治疗和保护作用的分子事件仍然难以捉摸。最近发现的FNDC5/irisin蛋白是由肌肉组织释放的运动反应可能是一个重要的发现，关于这个未解决的机制。这种肌细胞因子最引人注目的方面是它据称能够驱动棕色脂肪、白色脂肪的发育和产热。然而，这种新蛋白质的性质和分泌形式存在争议。本研究揭示，大鼠骨骼肌分泌25 kDa形式的FNDC5，而12 kDa/irisin理论肽未被检测到。更重要的是，这项研究首次揭示了白色脂肪组织（WAT）也分泌FNDC5;因此，它也可能表现为脂肪因子。我们使用大鼠脂肪组织外植体分泌组的数据证明，内脏脂肪组织（VAT），特别是皮下脂肪组织（SAT），表达和分泌FNDC5。我们还表明，短期耐力运动训练诱导FNDC5分泌SAT和VAT。此外，我们观察到WAT显著降低禁食动物的FNDC5分泌。有趣的是，肥胖动物的WAT过度分泌这种激素，这可能表明了一种抵抗力。由于72%的循环FNDC5/鸢尾素以前归因于肌肉分泌，我们的研究结果表明肌肉-脂肪组织串扰通过调节反馈机制。
Exercise provides clear beneficial effects for the prevention of numerous diseases. However, many of the molecular events responsible for the curative and protective role of exercise remain elusive. The recent discovery of FNDC5/irisin protein that is liberated by muscle tissue in response to exercise might be an important finding with regard to this unsolved mechanism. The most striking aspect of this myokine is its alleged capacity to drive brown-fat development of white fat and thermogenesis. However, the nature and secretion form of this new protein is controversial. The present study reveals that rat skeletal muscle secretes a 25 kDa form of FNDC5, while the 12 kDa/irisin theoretical peptide was not detected. More importantly, this study is the first to reveal that white adipose tissue (WAT) also secretes FNDC5; hence, it may also behave as an adipokine. Our data using rat adipose tissue explants secretomes proves that visceral adipose tissue (VAT), and especially subcutaneous adipose tissue (SAT), express and secrete FNDC5. We also show that short-term periods of endurance exercise training induced FNDC5 secretion by SAT and VAT. Moreover, we observed that WAT significantly reduced FNDC5 secretion in fasting animals. Interestingly, WAT of obese animals over-secreted this hormone, which might suggest a type of resistance. Because 72% of circulating FNDC5/irisin was previously attributed to muscle secretion, our findings suggest a muscle-adipose tissue crosstalk through a regulatory feedback mechanism.
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影响因子：
7.7
作者：
Saito M;Okamatsu-Ogura Y;Matsushita M;Watanabe K;Yoneshiro T;Nio-Kobayashi J;Iwanaga T;Miyagawa M;Kameya T;Nakada K;Kawai Y;Tsujisaki M
通讯作者：
Tsujisaki M
运动和PGC1alpha在炎症和慢性疾病中的作用。
影响因子：
64.8
作者：
Handschin, Christoph;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.
影响因子：
64.5
作者：
Puigserver, P;Wu, ZD;Spiegelman, BM
通讯作者：
Spiegelman, BM
影响因子：
8.9
作者：
Ibrahim, M. Mohsen
通讯作者：
Ibrahim, M. Mohsen
DOI：
10.1152/ajpendo.00057.2010
发表时间：
2010-09-01
影响因子：
5.1
作者：
Al-Massadi, O.;Crujeiras, A. B.;Seoane, L. M.
通讯作者：
Seoane, L. M.