Cardiac and vascular consequences of pre-hypertension in youth.
Cardiac and vascular consequences of pre-hypertension in youth.
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DOI：
10.1111/j.1751-7176.2011.00471.x
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Dolan LM
中科院分区：
文献类型：
--
作者：
Urbina EM;Khoury PR;McCoy C;Daniels SR;Kimball TR;Dolan LM
Hypertension (HT) is associated with increased LVM and carotid intima-media thickness (cIMT) which predict cardiovascular (CV) events in adults. Whether target organ damage (TOD) is found in prehypertensive youth (PreHT) is not known. We measured BMI, BP, fasting glucose, insulin, lipids and CRP, LVM/ht2.7 (LVMI), diastolic function, cIMT, carotid stiffness, augmentation index (AIx), brachial artery distensibility (BrachD), pulse wave velocity (PWV), in 723 subjects 10–23 yrs (29% type 2 diabetes mellitus, T2DM). Subjects were stratified by BP level (normotensive: NT=531, PreHT=65, HT=127). Adiposity and CV risk factors worsened across BP group. There was a graded increase in cIMT, arterial stiffness, and LVMI and decrease in diastolic function from NT to PreHT to HT. In multivariable models adjusted for CV risk factors, status as PreHT or HT remained an independent determinant of TOD for LVM, diastolic function, internal cIMT, carotid and arterial stiffness. PreHT is associated with CV TOD in adolescents and young adults.
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DOI：
10.1161/hypertensionaha.109.129031
发表时间：
2009-11
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
De Marco M;de Simone G;Roman MJ;Chinali M;Lee ET;Russell M;Howard BV;Devereux RB
通讯作者：
Devereux RB
影响因子：
19.6
作者：
Cadnapaphornchai, Melissa A.;McFann, Kim;Schrier, Robert W.
通讯作者：
Schrier, Robert W.
影响因子：
5.1
作者：
Daniels, SR;Witt, SA;Kimball, TR
通讯作者：
Kimball, TR
影响因子：
8.3
作者：
ARMENTANO, R;SIMON, A;PICHEL, R
通讯作者：
PICHEL, R
影响因子：
8.3
作者：
Blacher, J;Asmar, R;Safar, ME
通讯作者：
Safar, ME