The Role of Vitamin D and Oxidative Stress in Chronic Kidney Disease.
The Role of Vitamin D and Oxidative Stress in Chronic Kidney Disease.
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DOI：
10.3390/ijerph15122701
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发表时间：
2018-11-30
影响因子：
--
通讯作者：
Nicholas SB
中科院分区：
文献类型：
--
作者：
Norris KC;Olabisi O;Barnett ME;Meng YX;Martins D;Obialo C;Lee JE;Nicholas SB
慢性肾脏病（CKD）是一种主要的非传染性疾病，与过早发病率和死亡率高相关。维生素D缺乏症（25（OH）D或25 D缺乏）在少数民族和CKD患者中的患病率高于一般人群。低25 D与骨和矿物质紊乱以及免疫、心脏代谢和心血管（CV）疾病相关。因此，已表明低25 D有助于CKD患者的不良结局。维生素D缺乏症的患病率随着肾脏疾病严重程度的进展而逐渐升高，估计超过30%的CKD 3期患者和70%的CKD 5期患者的25 D水平较低。本报告描述了与CKD中低25 D相关的几种异常生理和反调节作用，例如氧化应激和炎症系统中的那些，以及一些临床前和临床证据，或缺乏这些证据，使血清25 D水平正常化以改善CKD患者的结局，特别是对于患有更高的晚期CKD和维生素D缺乏症的少数种族/民族的高风险子集。
Chronic kidney disease (CKD) is a major non-communicable disease associated with high rates of premature morbidity and mortality. The prevalence of hypovitaminosis D (deficiency of 25(OH)D or 25D) is greater in racial/ethnic minorities and in patients with CKD than the general population. Low 25D is associated with bone and mineral disorders as well as immune, cardiometabolic and cardiovascular (CV) diseases. Thus, it has been suggested that low 25D contributes to the poor outcomes in patients with CKD. The prevalence of hypovitaminosis D rises progressively with advancing severity of kidney disease with over 30% of patients with CKD stage 3 and 70% patients with CKD stage 5 estimated to have low levels of 25D. This report describes several of the abnormal physiologic and counter-regulatory actions related to low 25D in CKD such as those in oxidative stress and inflammatory systems, and some of the preclinical and clinical evidence, or lack thereof, of normalizing serum 25D levels to improve outcomes in patients with CKD, and especially for the high risk subset of racial/ethnic minorities who suffer from higher rates of advanced CKD and hypovitaminosis D.
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影响因子：
4
作者：
Gutierrez, O. M.;Farwell, W. R.;Kermah, D.;Taylor, E. N.
通讯作者：
Taylor, E. N.
DOI：
10.1038/ki.2009.188
发表时间：
2009-08-01
期刊：
Kidney international. Supplement
影响因子：
--
作者：
通讯作者：
--
DOI：
10.2215/cjn.05781207
发表时间：
2008-07-01
影响因子：
9.8
作者：
Mehrotra, Rajnish;Kermah, Dulcie;Norris, Keith
通讯作者：
Norris, Keith
DOI：
10.1111/j.1532-5415.2007.01048.x
发表时间：
2007-02-01
影响因子：
6.3
作者：
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通讯作者：
Kiel, Douglas P.
影响因子：
--
作者：
Martins, David;Wolf, Myles;Norris, Keith
通讯作者：
Norris, Keith