Time-dependent transformations of memory representations differ along the long axis of the hippocampus.
Time-dependent transformations of memory representations differ along the long axis of the hippocampus.
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记忆表征随时间发生的变化在海马体的长轴上存在差异。
DOI：
10.1101/lm.053438.121
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Davachi L
中科院分区：
文献类型：
--
作者：
Cowan ET;Liu AA;Henin S;Kothare S;Devinsky O;Davachi L
研究表明，睡眠有助于长期记忆的保持。根据记忆巩固理论，记忆会逐渐重新组织，尤其在编码后的睡眠阶段，会得到广泛分布的大脑皮层网络的支持。然而，睡眠对海马体自身记忆组织的影响仍不太明确。在一项为期3天的研究中，参与者对不同睡眠依赖巩固机会的单词 - 图像对列表进行编码。这些单词 - 图像对要么在夜间睡眠期之前学习，要么在之后学习，然后在功能性磁共振成像（fMRI）扫描环节中再次学习。我们采用多变量模式相似性分析，来研究巩固过程对海马体记忆表征的细微影响。我们提供的证据表明，随着巩固过程的进行，海马体沿长轴会出现分离现象，即睡眠前最初形成的物体 - 单词记忆的表征模式，在前部海马体中变得更加分化，而在后部海马体中则变得更加相似或重叠。前部海马体表征的分化与后续行为表现相关。此外，后部海马体中的表征重叠与其间慢波睡眠的时长相关。这些结果共同表明，依赖睡眠的巩固过程促进了记忆痕迹沿海马体长轴的重新组织。
Research has shown that sleep is beneficial for the long-term retention of memories. According to theories of memory consolidation, memories are gradually reorganized, becoming supported by widespread, distributed cortical networks, particularly during postencoding periods of sleep. However, the effects of sleep on the organization of memories in the hippocampus itself remains less clear. In a 3-d study, participants encoded separate lists of word–image pairs differing in their opportunity for sleep-dependent consolidation. Pairs were initially studied either before or after an overnight sleep period, and were then restudied in a functional magnetic resonance imaging (fMRI) scan session. We used multivariate pattern similarity analyses to examine fine-grained effects of consolidation on memory representations in the hippocampus. We provide evidence for a dissociation along the long axis of the hippocampus that emerges with consolidation, such that representational patterns for object–word memories initially formed prior to sleep become differentiated in anterior hippocampus and more similar, or overlapping, in posterior hippocampus. Differentiation in anterior hippocampal representations correlated with subsequent behavioral performance. Furthermore, representational overlap in posterior hippocampus correlated with the duration of intervening slow wave sleep. Together, these results demonstrate that sleep-dependent consolidation promotes the reorganization of memory traces along the long axis of the hippocampus.
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影响因子：
16.6
作者：
Dandolo LC;Schwabe L
通讯作者：
Schwabe L
影响因子：
5.3
作者：
Ezzyat, Youssef;Inhoff, Marika C.;Davachi, Lila
通讯作者：
Davachi, Lila
影响因子：
3.5
作者：
Bosshardt, S;Degonda, N;Henke, K
通讯作者：
Henke, K
影响因子：
5.3
作者：
Andrade, Katia C.;Spoormaker, Victor I.;Czisch, Michael
通讯作者：
Czisch, Michael
空间记忆之间的重叠会触发海马表示的排斥。
DOI：
10.1016/j.cub.2017.06.057
发表时间：
2017-08-07
期刊：
Current biology : CB
影响因子：
--
作者：
Chanales AJH;Oza A;Favila SE;Kuhl BA
通讯作者：
Kuhl BA