The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL).
The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL).
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DOI：
10.3390/brainsci12040485
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发表时间：
2022-04-08
期刊：
影响因子：
3.3
通讯作者：
Zuidema, Sytse U.
中科院分区：
文献类型：
--
作者：
Rasing, Naomi L.;Janus, Sarah I. M.;Kreutz, Gunter;Sveinsdottir, Vigdis;Gold, Christian;Nater, Urs M.;Zuidema, Sytse U.
关键词：
最近，设计了一项大型整群随机对照试验-老年护理中的音乐干预痴呆症和抑郁(Middel)-以评估音乐干预对患有痴呆症的疗养院居民抑郁的有效性(ClinicalTrials.gov NCT03496675)。为了了解其病理生理机制，我们观察了反复音乐干预对这一人群压力的影响，因为慢性压力与抑郁和痴呆症风险增加有关。一项探索性研究旨在评估：(1)头发皮质醇浓度的变化作为长期应激的指标；(2)基线应激是否可预测治疗结果；(3)作为即时应激指标的180-200名参加Middel试验的疗养院居民在治疗前后对唾液α-淀粉酶和皮质醇反应的影响作为即时应激指标。我们将深入了解压力的中介作用，以解释音乐干预的效果。在基线、3个月、6个月和12个月时，用感觉应激量表评估头发皮质醇浓度。在1、3和6个月时评估唾液α-淀粉酶和皮质醇浓度。在治疗前、治疗后15分钟和60分钟收集唾液，并进行压力视觉模拟评分。
Recently, a large cluster-randomized controlled trial was designed—Music Interventions for Dementia and Depression in ELderly care (MIDDEL)—to assess the effectiveness of music interventions on depression in care home residents with dementia (ClinicalTrials.gov NCT03496675). To understand the pathophysiological mechanisms, we observed the effect of repeated music interventions on stress in this population since chronic stress was associated with depression and an increased risk for dementia. An exploratory study was designed to assess: (1) changes in hair cortisol concentrations as an indicator of longer-term stress; (2) whether baseline stress is a predictor of therapy outcome; (3) pre- and post-treatment effects on salivary α-amylase and cortisol response as an indicator of immediate stress in 180–200 care home residents with dementia and depressive symptoms who partake in the MIDDEL trial. Insights into mediatory effects of stress to explain the effect of music interventions will be gained. Hair cortisol concentrations were assessed at baseline and at 3, 6, and 12 months along with the Perceived Stress Scale. Salivary α-amylase and cortisol concentrations were assessed at 1, 3, and 6 months. Saliva was collected just before a session and 15 and 60 min after a session, along with a stress Visual Analogue Scale.
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