Putative effects of endocrine disrupters on pubertal development in the human.

Putative effects of endocrine disrupters on pubertal development in the human.
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内分泌干​​扰物对人类青春期发育的假定影响。

DOI:
10.1053/beem.2002.0184
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发表时间:
2002
期刊:
Best practice & research. Clinical endocrinology & metabolism
影响因子:
--
通讯作者:
J. Toppari
J. Toppari
中科院分区:
--
文献类型:
--
作者:
G. Teilmann;A. Juul;N. Skakkebaek;J. Toppari

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青春期发育受促性腺激素和性激素的调节。在上个世纪,青春期的时间有一个明显的长期趋势,青春期变得更早。尽管营养改善被认为是原因,但这可能在一定程度上与接触所谓的内分泌干扰物有关。在几个意外接触化妆品、食品和药品中的雌激素化合物的病例报告中描述了性早熟。局部流行的乳房早熟也被认为与内分泌干扰物有关。从发展中国家领养到工业化国家的儿童往往会发展为性早熟。理论上,不仅性早熟,而且青春期延迟都与暴露于内分泌干扰物有关。虽然内分泌干扰物可能会干扰青春期发育是很有可能的,但关于这方面的研究很少,因此,我们还没有任何明确的人类因果关系。
Pubertal development is regulated by gonadotrophins and sex hormones. There has been a clear secular trend in the timing of puberty during the last century, puberty becoming earlier. Although improved nutrition is assumed to be the cause, this could partly be associated with exposure to so-called endocrine disrupters. Precocious puberty has been described in several case reports of accidental exposure to oestrogenic compounds in cosmetic products, food and pharmaceuticals. Local epidemics of premature thelarche have also been suggested to be linked to endocrine disrupters. Children adopted from developing countries to industrialized countries often develop precocious puberty. Not only precocious puberty, but also delayed puberty can, theoretically, be associated with exposure to endocrine disrupters. While it is very plausible that endocrine disrupters may disturb pubertal development, there is very little research on this and, therefore, we do not yet have any clear cause-effect relationships in humans.
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