A chemically polymerized electrically conducting composite of polypyrrole nanoparticles and polyurethane for tissue engineering.
A chemically polymerized electrically conducting composite of polypyrrole nanoparticles and polyurethane for tissue engineering.
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DOI：
10.1002/jbm.a.33128
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发表时间：
2011-09-15
影响因子：
4.9
通讯作者：
Harrison, Benjamin S.
中科院分区：
文献类型：
--
作者：
Broda, Christopher R.;Lee, Jae Y.;Sirivisoot, Sirinrath;Schmidt, Christine E.;Harrison, Benjamin S.
多种类型的细胞对电刺激有反应，因此许多导电聚合物（CP）被用作组织工程（TE）支架，聚吡咯（PPy）就是其中之一。PPy是一种研究充分的生物材料，由于其导电性和许多其他有益的特性，具有潜在的TE应用。将其特性与弹性体材料（例如聚氨酯（PU））相结合，可以产生具有电活性和显著机械弹性的混合支架。吡咯分别以1：100、1：20、1：10和1：5的重量比在PU乳液混合物中原位聚合。形态，电导率，机械性能和与C2 C12成肌细胞的细胞相容性进行了表征。聚合反应导致了一种复合材料，其主要基础是PU，其中散布着PPy纳米颗粒的电致变色网络。随着PPy/PU质量比的增加，复合材料的电导率也随之增加。随着PPy/PU质量比的增加，复合材料的刚度增加，最大拉伸长度减小。在所有样品中，向PU基料中加入PPy后，极限拉伸强度降低约47%。细胞相容性试验数据表明复合材料没有显著的细胞毒性作用。C2 C12细胞的静态细胞接种和随后的分化显示在复合材料上形成肌管。
A variety of cell types respond to electrical stimuli, accordingly many conducting polymers (CPs) have been used as tissue engineering (TE) scaffolds, one such CP is polypyrrole (PPy). PPy is a well studied biomaterial with potential TE applications due to its electrical conductivity and many other beneficial properties. Combining its characteristics with an elastomeric material, such as polyurethane (PU), may yield a hybrid scaffold with electrical activity and significant mechanical resilience. Pyrrole was in situ polymerized within a PU emulsion mixture in weight ratios of 1:100, 1:20, 1:10 and 1:5, respectively. Morphology, electrical conductivity, mechanical properties and cytocompatibility with C2C12 myoblast cells were characterized. The polymerization resulted in a composite with a principle base of PU interspersed with an electrically percolating network of PPy nanoparticles. As the mass ratio of PPy to PU increased so did electrical conductivity of the composites. In addition, as the mass ratio of PPy to PU increased, stiffness of the composite increased while maximum elongation length decreased. Ultimate tensile strength was reduced by approximately 47% across all samples with the addition of PPy to the PU base. Cytocompatibility assay data indicated no significant cytotoxic effect from the composites. Static cellular seeding of C2C12 cells and subsequent differentiation showed myotube formation on the composite materials.
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影响因子：
5.5
作者：
Guimard, Nathalie K. E.;Sessler, Jonathan L.;Schmidt, Christine E.
通讯作者：
Schmidt, Christine E.
DOI：
10.1097/01.blo.0000031973.69509.21
发表时间：
2002-10-01
影响因子：
4.2
作者：
Sanger, JW;Chowrashi, P;Sanger, JM
通讯作者：
Sanger, JM
影响因子：
4.4
作者：
BI, XT;PEI, QB
通讯作者：
PEI, QB
影响因子：
14
作者：
Miller, DC;Thapa, A;Webster, TJ
通讯作者：
Webster, TJ
影响因子：
64.8
作者：
BASSETT, CA;PAWLUK, RJ;BECKER, RO
通讯作者：
BECKER, RO