Biodistribution of encapsulated indocyanine green in healthy mice.
Biodistribution of encapsulated indocyanine green in healthy mice.
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DOI：
10.1021/mp800270t
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发表时间：
2009-09
影响因子：
4.9
通讯作者：
Anvari B
中科院分区：
文献类型：
--
作者：
Yaseen MA;Yu J;Jung B;Wong MS;Anvari B
Indocyanine Green (ICG) is a fluorescent probe used in various optically-mediated diagnostic and therapeutic applications. However, utility of ICG remains limited by its unstable optical properties and non-specific localization. We have encapsulated ICG within electrostatically-assembled mesocapsules (MCs) to explore its potential for targeted optical diagnosis and therapy. In this study, we investigate how the surface coating and size of the MCs influences ICG's biodistribution in vivo. ICG was administered intravenously to Swiss Webster mice as a free solution or encapsulated within either 100 nm diameter MCs coated with dextran; 500 nm diameter MCs coated with dextran; or 100 nm diameter MCs coated with 10 nm ferromagnetic iron oxide nanoparticles, themselves coated with polyethylene glycol. ICG was extracted from harvested blood and organs at various times and its amount quantified with fluorescence measurements. MCs containing ICG accumulated in organs of the reticuloendothelial system, namely the liver and spleen, as well as the lungs. The circulation kinetics of ICG remained unaffected by encapsulation; however, the deposition within organs other than the liver suggests a different biodistribution mechanism. Results suggest that the capsules' coating influences their biodistribution to a greater extent than their size. The MC encapsulation system allows for delivery of ICG to organs other than the liver, enabling the potential development of new optical imaging and therapeutic strategies.
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影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
DOI：
10.1016/s1011-1344(96)07453-2
发表时间：
1997-04-01
影响因子：
5.4
作者：
Fickweiler, S;Szeimies, RM;Landthaler, M
通讯作者：
Landthaler, M
DOI：
10.1073/pnas.0702427104
发表时间：
2007-05-29
影响因子：
11.1
作者：
de Chermont, Quentin le Masne;Chaneac, Corinne;Scherman, Daniel
通讯作者：
Scherman, Daniel
影响因子：
14
作者：
Hirata, Y;Aoki, M;Yamamoto, H
通讯作者：
Yamamoto, H
影响因子：
2.1
作者：
Devoisselle, JM;Soulié-Bégu, S;Maillols, H
通讯作者：
Maillols, H