Identification of an oral microbiota signature associated with an impaired orosensory perception of lipids in insulin-resistant patients.
Identification of an oral microbiota signature associated with an impaired orosensory perception of lipids in insulin-resistant patients.
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鉴定与胰岛素耐药性患者脂质的口腔感觉受损相关的口服微生物群。
DOI：
10.1007/s00592-020-01567-9
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发表时间：
2020-12
影响因子：
3.8
通讯作者：
Burcelin R
中科院分区：
文献类型：
--
作者：
Besnard P;Christensen JE;Bernard A;Simoneau-Robin I;Collet X;Verges B;Burcelin R
2型糖尿病导致多种感觉功能障碍，特别影响味觉敏感性。虽然这种感官缺陷通过影响食物选择可能导致不健康的饮食行为，但其潜在机制仍然研究甚少。我们最近报道了与轮廓味觉乳头接触的微生物群的组成可能会影响瘦和血糖正常的肥胖受试者对脂质的口腔感觉。这一发现促使我们探索这种现象是否也发生在糖尿病肥胖患者中。结合男性胰岛素抵抗患者和体重匹配的健康对照者的亚油酸感知阈值，分析轮廓乳头周围的微生物群组成。进行了两个互补比较：（1）对照组与糖尿病组，以及（2）糖尿病低脂品尝者与糖尿病高脂品尝者。尽管在口腔微生物群组成的微妙的修改，在控制和糖尿病受试者的orosensory脂质感知的比较并没有导致歧视的数据，由于亚油酸感知阈值的大的个体间变异性。相比之下，通过比较导致差异分子途径的糖尿病低脂和高脂味觉者，发现了特定的细菌特征。令人惊讶的是，主要在用二甲双胍和/或他汀类药物治疗的患者中发现较低的脂肪味觉，这表明这些抗糖尿病和/或降血脂药物对味觉敏锐度的可能副作用。总的来说，这些数据表明，具有脂肪味检测缺陷的糖尿病患者的特征在于轮廓乳头水平的特定微生物群代谢，这种情况似乎被通常用于抵消T2 D的破坏性代谢作用的药物放大。原始既往研究的试验注册：ClinicalTrials.gov #NCT02028975
Type 2 diabetes leads to multiple sensory dysfunctions affecting notably the gustatory sensitivity. Although this sensory defect, by impacting food choices, might lead to unhealthy eating behavior, underlying mechanisms remains poorly studied. We have recently reported that the composition of microbiota in contact with circumvallate gustatory papillae might affect the orosensory perception of lipids in lean and normoglycemic obese subjects. This finding has prompted us to explore whether such a phenomenon also occurs in diabetic obese patients. The composition of microbiota surrounding the circumvallate papillae was analyzed in combination with the linoleic acid perception thresholds in male insulin-resistant patients and weight-matched healthy controls. Two complementary comparisons were performed: (1) controls vs diabetic and (2) diabetic low-lipid tasters versus diabetic high-lipid tasters. Despite subtle modifications in the oral microbiota composition, comparison of orosensory lipid perception in controls and diabetic subjects did not lead to discriminating data due to the large inter-individual variability of linoleic acid perception thresholds. In contrast, specific bacterial signatures were found by comparing diabetic low- and high-lipid tasters leading to differential molecular pathways. Surprisingly, a lower fatty taste perception was mainly found in patients treated with metformin and/or statins, suggesting a possible side effect of these antidiabetic and/or hypolipidemic drugs on taste acuity. Collectively, these data show that the diabetic patients with defective fatty taste detection are characterized by a specific microbiota metabolism at the circumvallate papillae levels, this occurrence seeming amplified by drugs commonly used to counteract the damaging metabolic effects of T2D. Trial registration for original previous studies: ClinicalTrials.gov #NCT02028975
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影响因子：
7.1
作者：
Chevrot, Michael;Passilly-Degrace, Patricia;Besnard, Philippe
通讯作者：
Besnard, Philippe
影响因子：
82.9
作者：
Wu, Hao;Esteve, Eduardo;Backhed, Fredrik
通讯作者：
Backhed, Fredrik
影响因子：
5.3
作者：
Heath, Tom P.;Melichar, Jan K.;Donaldson, Lucy F.
通讯作者：
Donaldson, Lucy F.
影响因子：
3.5
作者：
Chale-Rush, Angela;Burgess, John R.;Mattes, Richard D.
通讯作者：
Mattes, Richard D.
DOI：
10.1016/j.dsx.2019.06.021
发表时间：
2019-07-01
影响因子：
10
作者：
Brindisi, Marie-Claude;Brondel, Laurent;Penicaud, Luc
通讯作者：
Penicaud, Luc