Association Between Homocysteine and Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis
Association Between Homocysteine and Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis
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同型半胱氨酸与 2 型糖尿病之间的关联：系统评价和荟萃分析
DOI：
10.1007/s13410-021-00933-9
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发表时间：
2021-02
影响因子：
0.9
通讯作者：
Lanqing Ma
中科院分区：
文献类型：
--
作者：
Jinxiang Wang;Dingyun You;Huaping Wang;Chenggang Zou;Yanhong Yang;Dan Zhang;Mingke Li;Chunmei Li;Junyan Lv;Sufeng Luo;Xue Yu;Rui Liao;Lanqing Ma
高同型半胱氨酸血症与2型糖尿病(T2 DM)的关系已有多项研究。然而，得到了不一致的结果。我们在PubMed、Cochrane图书馆和EMBASE数据库中搜索了从成立到2019年6月评估血液同型半胱氨酸(HCY)水平与T2 DM关系的研究。所有纳入研究的质量通过纽卡斯尔渥太华量表(NOS)和卫生保健研究质量机构(AHRQ)进行评估。结果共纳入25篇T2 DM血同型同型半胱氨酸水平的研究(包括1881例病例和2868例对照)。未考虑年龄、性别、心脑血管疾病等合并症的影响，T2 DM患者的血同型同型半胱氨酸水平显著高于健康人(P<0.001)，95%CI=0.43~0.84，P<0.001。此外，2型糖尿病合并肾病或视网膜病变患者的血同型同型半胱氨酸水平也显著高于单纯2型糖尿病患者(P<0.001)；I2=90%，P<0.001；结论我们的Meta分析显示T2 DM患者血中HCY水平明显高于正常人，尤其是合并糖尿病肾病(DN)和糖尿病视网膜病变(DR)的患者。
BackgroundSeveral studies have been performed to assess the relationship between hyperhomocysteinemia and type 2 diabetes mellitus (T2DM). However, inconsistent results have been obtained. Therefore, we performed this meta-analysis to address this knowledge gap.MethodsWe searched PubMed, Cochrane library, and EMBASE database for studies that evaluated the relationship between blood homocysteine (HCY) level and T2DM from inception to Jun 2019. The quality of all included studies was assessed by the Newcastle Ottawa Scale (NOS) and the Agency for Healthcare Research Quality (AHRQ). RevMan5.3 and Stata12.0 were used for data analyses.ResultsTwenty-five studies (including 1881 cases and 2868 controls) on blood HCY level in T2DM were pooled in our meta-analysis. The blood HCY level in the T2DM patients was significantly higher than in the healthy individuals (SMD = 0.63, 95% CI = 0.43–0.84, andp< 0.001,I2= 89%,p< 0.001), ignores the effects of age, sex, cardiovascular and cerebrovascular disease conditions, and other comorbidity. Additionally, in T2DM patients with nephropathy or retinopathy, blood HCY level was also significantly higher than in those with only T2DM (SMD = 1.17, 95% CI = 0.76–1.58,p< 0.001;I2= 90%,p< 0.001 and SMD = 0.91, 95% CI = 0.39–1.44,p <0.001;I2= 82%,p <0.001, respectively).ConclusionOur meta-analysis revealed the HCY level in the blood of T2DM patients was significantly higher than those of the health subjects, especially in patients with diabetic nephropathy (DN) and diabetic retinopathy (DR).
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影响因子：
3
作者：
S. Das;Tammy Reynolds;A. Patnaik;N. Rais;L. Fink;V. Fonseca
通讯作者：
S. Das;Tammy Reynolds;A. Patnaik;N. Rais;L. Fink;V. Fonseca
影响因子：
5.1
作者：
Guariguata, L.;Whiting, D. R.;Shaw, J. E.
通讯作者：
Shaw, J. E.
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
5.3
作者：
Sofi, Francesco;Marcucci, Rossella;Prisco, Domenico
通讯作者：
Prisco, Domenico
影响因子：
16.2
作者：
Aso, Y;Okumura, K;Inukai, T
通讯作者：
Inukai, T