Simultaneous exposure to multiple heavy metals and glyphosate may contribute to Sri Lankan agricultural nephropathy.
Simultaneous exposure to multiple heavy metals and glyphosate may contribute to Sri Lankan agricultural nephropathy.
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DOI：
10.1186/s12882-015-0109-2
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发表时间：
2015-07-11
期刊：
影响因子：
2.3
通讯作者：
Siribaddana S
中科院分区：
文献类型：
--
作者：
Jayasumana C;Gunatilake S;Siribaddana S
斯里兰卡农业肾病（Sri Lankan Agricultural Nephropathy， SAN）是一种发生在稻田农民中的新型慢性肾脏疾病，于1994年首次报道。它现在已成为斯里兰卡干旱地区最严重的公共卫生问题。先前的研究表明SAN是一种小管间质型肾病，暴露于砷和镉可能在该疾病的发病机制中起作用。对来自疾病流行地区padavii - sripura的SAN患者（N = 10）和来自两组对照的尿液样本进行了分析，其中一组来自同一流行地区的健康参与者（N = 10），另一组来自非流行地区（N = 10；科伦坡地区），分析了19种重金属和农药草甘膦的存在。在这两例病例和生活在流行地区的对照组中，尿中Sb、As、Cd、Co、Pb、Mn、Ni、Ti和V的浓度中位数超过了参考范围。除患者中的Mo和地方病对照中的Al、Cu、Mo、Se、Ti和Zn外，尿中重金属和草甘膦的肌酐校正值均显著高于非地方病对照。与非地方病对照相比，地方病对照研究的20种化学物质中有14种和患者研究的7种未经调整的肌酐值显著高于地方病对照。尿草甘膦浓度最高的是SAN患者（61.0-195.1 μg/g肌酐）。疾病流行地区暴露于多种重金属和草甘膦的人群。结果支持SAN毒理学来源仅限于特定地理区域。虽然我们不能确定单一的肾毒素是SAN的罪魁祸首，但多种重金属和草甘膦可能在发病机制中起作用。在SAN患者的尿液样本中过量存在的重金属可能会对肾脏造成损害。多种重金属与农用化学品的协同作用可能产生肾毒性。
Sri Lankan Agricultural Nephropathy (SAN), a new form of chronic kidney disease among paddy farmers was first reported in 1994. It has now become the most debilitating public health issue in the dry zone of Sri Lanka. Previous studies showed SAN is a tubulo-interstitial type nephropathy and exposure to arsenic and cadmium may play a role in pathogenesis of the disease. Urine samples of patients with SAN (N = 10) from Padavi-Sripura, a disease endemic area, and from two sets of controls, one from healthy participants (N = 10) from the same endemic area and the other from a non-endemic area (N = 10; Colombo district) were analyzed for 19 heavy metals and for the presence of the pesticide- glyphosate. In both cases and the controls who live in the endemic region, median concentrations of urinary Sb, As, Cd, Co, Pb, Mn, Ni, Ti and V exceed the reference range. With the exception of Mo in patients and Al, Cu, Mo, Se, Ti and Zn in endemic controls, creatinine adjusted values of urinary heavy metals and glyphosate were significantly higher when compared to non-endemic controls. Creatinine unadjusted values were significant higher for 14 of the 20 chemicals studied in endemic controls and 7 in patients, compared to non-endemic controls. The highest urinary glyphosate concentration was recorded in SAN patients (range 61.0-195.1 μg/g creatinine). People in disease endemic area exposed to multiple heavy metals and glyphosate. Results are supportive of toxicological origin of SAN that is confined to specific geographical areas. Although we could not localize a single nephrotoxin as the culprit for SAN, multiple heavy metals and glyphosates may play a role in the pathogenesis. Heavy metals excessively present in the urine samples of patients with SAN are capable of causing damage to kidneys. Synergistic effects of multiple heavy metals and agrochemicals may be nephrotoxic.
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影响因子：
13.2
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
3.5
作者：
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通讯作者：
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影响因子：
2.3
作者：
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通讯作者：
CKDu National Research Project Team
影响因子：
4.3
作者：
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通讯作者：
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