Innate Pulmonary Phagocytes and Their Interactions with Pathogenic Cryptococcus Species.

Innate Pulmonary Phagocytes and Their Interactions with Pathogenic Cryptococcus Species.
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DOI:
10.3390/jof9060617
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发表时间:
2023-05-27
期刊:
Journal of fungi (Basel, Switzerland)
影响因子:
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其他
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新型隐球菌是一种机会性真菌病原体,每年导致超过180,000例HIV/AIDS患者死亡。肺部的先天吞噬细胞,如树突状细胞(DC)和巨噬细胞,是第一个与病原体相互作用的细胞。中性粒细胞,另一种先天性吞噬细胞,在隐球菌感染期间被招募到肺部。这些先天细胞参与C的早期检测。新型球菌,以及隐球菌感染的去除和清除。然而,C.新形式的人已经开发出干扰这些过程的方法,允许逃避宿主的先天免疫系统。此外,先天免疫细胞具有帮助隐球菌发病的能力。本文就近年来有关先天性肺吞噬细胞与C.新人类
Cryptococcus neoformans is an opportunistic fungal pathogen that causes over 180,000 annual deaths in HIV/AIDS patients. Innate phagocytes in the lungs, such as dendritic cells (DCs) and macrophages, are the first cells to interact with the pathogen. Neutrophils, another innate phagocyte, are recruited to the lungs during cryptococcal infection. These innate cells are involved in early detection of C. neoformans, as well as the removal and clearance of cryptococcal infections. However, C. neoformans has developed ways to interfere with these processes, allowing for the evasion of the host’s innate immune system. Additionally, the innate immune cells have the ability to aid in cryptococcal pathogenesis. This review discusses recent literature on the interactions of innate pulmonary phagocytes with C. neoformans.
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