Collective migration and cell jamming.
Collective migration and cell jamming.
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DOI：
10.1016/j.diff.2013.02.005
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发表时间：
2013-10
期刊：
影响因子：
2.9
通讯作者：
Fredberg, Jeffrey J.
中科院分区：
文献类型：
--
作者：
Sadati, Monirosadat;Qazvini, Nader Taheri;Krishnan, Ramaswamy;Park, Chan Young;Fredberg, Jeffrey J.
我们传统的物理图像与直觉概念保持一致，即组成细胞集体的每个单个细胞感知信号或梯度，然后动员物理力量作出反应。这些力量反过来又驱动局部细胞运动，从而出现集体细胞迁移。虽然它没有考虑到可能相当大的自发噪声波动，但默认的假设是线性因果关系之一，其中系统的局部运动平均而言是局部力的影子，而这些局部力是局部信号的影子。现在，新的证据表明了一种完全不同的物理图景，其中占主导地位的机械事件可能不是局部的，机械因果关系的级联可能不是线性的，而且令人惊讶的是，波动可能不是噪音，因为它们是机制的基本特征。在这里，我们认为一种新的合成中，波动和非本地的合作事件，典型的细胞集体可能会照亮的统一概念的细胞干扰。干扰有可能将各种已知的因素结合起来，但以前大多数情况下被认为是单独和独立的。这些包括细胞拥挤、细胞间力传递、钙粘蛋白依赖性细胞-细胞粘附、整合素依赖性细胞-基质粘附、肌球蛋白依赖性运动力和收缩力、肌动蛋白依赖性变形性、增殖、压缩和拉伸。
Our traditional physical picture holds with the intuitive notion that each individual cell comprising the cellular collective senses signals or gradients and then mobilizes physical forces in response. Those forces, in turn, drive local cellular motions from which collective cellular migrations emerge. Although it does not account for spontaneous noisy fluctuations that can be quite large, the tacit assumption has been one of linear causality in which systematic local motions, on average, are the shadow of local forces, and these local forces are the shadow of the local signals. New lines of evidence now suggest a rather different physical picture in which dominant mechanical events may not be local, the cascade of mechanical causality may be not so linear, and, surprisingly, the fluctuations may not be noise as much as they are an essential feature of mechanism. Here we argue for a novel synthesis in which fluctuations and non-local cooperative events that typify the cellular collective might be illuminated by the unifying concept of cell jamming. Jamming has the potential to pull together diverse factors that are already known to contribute but previously had been considered for the most part as acting separately and independently. These include cellular crowding, intercellular force transmission, cadherin-dependent cell-cell adhesion, integrin-dependent cell-substrate adhesion, myosin-dependent motile force and contractility, actin-dependent deformability, proliferation, compression and stretch.
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影响因子：
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