Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications.
Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications.
复制标题
衰老的荷尔蒙和代谢变化以及生活方式改变的影响。
DOI：
10.1016/j.mayocp.2020.07.033
复制
发表时间：
2021-03
影响因子：
8.9
通讯作者：
Nair KS
中科院分区：
文献类型：
--
作者：
Pataky MW;Young WF;Nair KS
预期寿命的延长，加上婴儿潮一代的老龄化，导致了全球老年人口前所未有的增长。老年人人口的增长和与年龄有关的慢性病发病率的增加造成了巨大的社会经济负担。随着年龄的增长，激素的产生和活动逐渐减少，增加了患慢性病的风险，缩短了寿命，对人类健康产生了不利影响。在这里，我们回顾了与年龄相关的激素产生的下降，以及与年龄相关的生化和身体成分的变化，这些变化降低了某些激素的生物利用度和作用。还讨论了激素变化对各种慢性疾病的影响，包括虚弱、糖尿病、心血管疾病和痴呆症。激素替代疗法已经在许多临床试验中被尝试以逆转和/或防止荷尔蒙在衰老中的下降，以对抗与年龄相关的疾病的进展。不幸的是，激素替代疗法不是灵丹妙药，因为它经常导致各种不良事件，超过其潜在的健康益处。因此，除个别病例外，不推荐使用激素替代疗法。相反，积极的生活方式改变，如定期的有氧运动和抵抗力运动计划和/或健康的卡路里限制饮食，可以有利地影响内分泌和代谢功能，并作为各种与年龄相关的疾病的对策。在这里，我们对现有数据进行了批判性的回顾，并提出了建议，希望这些建议将成为医生/科学家开发和优化新的内分泌靶向治疗和生活方式调整的基础，这些治疗和生活方式调整可以更好地解决与年龄相关的健康下降问题。
Increased life expectancy combined with the aging Baby Boomer Generation has resulted in an unprecedented global expansion of the elderly population. The growing population of older adults and increased rate of age-related chronic illness has caused a substantial socio-economic burden. The gradual and progressive age-related decline in hormone production and action has a detrimental impact on human health by increasing risk for chronic disease and reducing life span. Here we review the age-related decline in hormone production, as well as age-related biochemical and body composition changes that reduce the bioavailability and actions of some hormones. The impact of hormonal changes on various chronic conditions including frailty, diabetes, cardiovascular disease and dementia are also discussed. Hormone replacement therapy has been attempted in many clinical trials to reverse and/or prevent the hormonal decline in aging to combat the progression of age-related diseases. Unfortunately, hormone replacement therapy is not a panacea, as it often results in various adverse events which outweigh its potential health benefits. Therefore, except in some specific individual cases, hormone replacement is not recommended. Rather, positive lifestyle modifications such as regular aerobic and resistance exercise programs and/or healthy calorically restricted diet can favorably affect endocrine and metabolic functions and act as countermeasures to various age-related diseases. Here we provide a critical review of the available data and offer recommendations which hopefully will form the groundwork for physicians/scientists to develop and optimize new endocrine-targeted therapies and lifestyle modifications that can better address age-related decline in heath.
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DOI：
10.1056/nejmoa1000485
发表时间：
2010-07-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Basaria S;Coviello AD;Travison TG;Storer TW;Farwell WR;Jette AM;Eder R;Tennstedt S;Ulloor J;Zhang A;Choong K;Lakshman KM;Mazer NA;Miciek R;Krasnoff J;Elmi A;Knapp PE;Brooks B;Appleman E;Aggarwal S;Bhasin G;Hede-Brierley L;Bhatia A;Collins L;LeBrasseur N;Fiore LD;Bhasin S
通讯作者：
Bhasin S
影响因子：
7.7
作者：
Basu, Rita;Dalla Man, Chiara;Rizza, Robert A.
通讯作者：
Rizza, Robert A.
DOI：
10.1111/j.1532-5415.1998.tb01036.x
发表时间：
1998-03-01
影响因子：
6.3
作者：
Abbasi, A;Duthie, EH;Mattson, DE
通讯作者：
Mattson, DE
DOI：
10.1016/s0889-8529(05)70206-1
发表时间：
2001-09-01
影响因子：
4.5
作者：
Anawalt, BD;Merriam, GR
通讯作者：
Merriam, GR
影响因子：
16.2
作者：
Basu, Rita;Dalla Man, Chiara;Rizza, Robert A.
通讯作者：
Rizza, Robert A.