Olfaction and Anxiety Are Differently Associated in Men and Women in Cognitive Physiological and Pathological Aging.
Olfaction and Anxiety Are Differently Associated in Men and Women in Cognitive Physiological and Pathological Aging.
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DOI：
10.3390/jcm12062338
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发表时间：
2023-03-17
影响因子：
3.9
通讯作者：
Caldwell, Jessica Zoe Kirkland
中科院分区：
文献类型：
--
作者：
Cieri, Filippo;Cera, Nicoletta;Ritter, Aaron;Cordes, Dietmar;Caldwell, Jessica Zoe Kirkland
Background: Olfaction impairment in aging is associated with increased anxiety. We explored this association in cognitively healthy controls (HCs), Mild Cognitive Impairment (MCI) and Parkinson’s disease (PD) patients. Both olfaction and anxiety have sex differences, therefore we also investigated these variances. Objectives: Investigate the association of olfaction with anxiety in three distinct clinical categories of aging, exploring the potential role of sex. Methods: 117 subjects (29 HCs, 43 MCI, and 45 PD patients) were assessed for olfaction and anxiety. We used regression models to determine whether B-SIT predicted anxiety and whether sex impacted that relationship. Results: Lower olfaction was related to greater anxiety traits in all groups (HCs: p = 0.015; MCI: p = 0.001 and PD: p = 0.038), significantly differed by sex. In fact, in HCs, for every unit increase in B-SIT, anxiety traits decreased by 7.63 in men (p = 0.009) and 1.5 in women (p = 0.225). In MCI patients for every unit increase in B-SIT, anxiety traits decreased by 1.19 in men (p = 0.048) and 3.03 in women (p = 0.0036). Finally, in PD patients for every unit increase in B-SIT, anxiety traits decreased by 1.73 in men (p = 0.004) and 0.41 in women (p = 0.3632). Discussion: Olfaction and anxiety are correlated in all three distinct diagnostic categories, but differently in men and women.
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影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M
影响因子：
5.6
作者：
Gopinath, Bamini;Schneider, Julie;Mitchell, Paul
通讯作者：
Mitchell, Paul
影响因子：
2.9
作者：
Cerf-Ducastel, B;Murphy, C
通讯作者：
Murphy, C
DOI：
10.18632/aging.100149
发表时间：
2010-05
期刊：
Aging
影响因子：
--
作者：
Blagosklonny MV
通讯作者：
Blagosklonny MV
DOI：
10.3233/jad-180028
发表时间：
2018
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Caldwell JZK;Berg JL;Shan G;Cummings JL;Banks SJ;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative