What the reproductive number R(0) can and cannot tell us about COVID-19 dynamics.

What the reproductive number R(0) can and cannot tell us about COVID-19 dynamics.
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DOI:
10.1016/j.tpb.2020.12.003
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发表时间:
2021-03
影响因子:
1.4
通讯作者:
Kennedy DA
Kennedy DA
中科院分区:
生物学4区
文献类型:
--
作者:
Shaw CL;Kennedy DA

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生殖数(或免疫初始群体的初始生殖数)长期以来一直被成功地用于预测病原体入侵的可能性,衡量流行病的潜在严重性,并围绕干预措施制定政策。然而,经常被忽视的复杂性已经在度量的使用方面产生了混乱。这一点在新出现的大流行性病毒SARS-CoV-2(COVID-19的病原体)中尤为明显。我们解决了一些误解的预测能力的生殖数,专注于它如何随时间变化,随空间变化,并涉及到流行病的规模,通过引用的数学定义和例子,从目前的流行病。我们希望,更好地理解SARS-CoV-2的用途、细微差别和局限性,有助于更好地理解流行病的传播、流行病的严重程度和干预措施的效果。
The reproductive number (or , the initial reproductive number in an immune-naïve population) has long been successfully used to predict the likelihood of pathogen invasion, to gauge the potential severity of an epidemic, and to set policy around interventions. However, often ignored complexities have generated confusion around use of the metric. This is particularly apparent with the emergent pandemic virus SARS-CoV-2, the causative agent of COVID-19. We address some misconceptions about the predictive ability of the reproductive number, focusing on how it changes over time, varies over space, and relates to epidemic size by referencing the mathematical definition of and examples from the current pandemic. We hope that a better appreciation of the uses, nuances, and limitations of and facilitates a better understanding of epidemic spread, epidemic severity, and the effects of interventions in the context of SARS-CoV-2.
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