Altered resting-state connectivity in college students with nonclinical depressive symptoms.
Altered resting-state connectivity in college students with nonclinical depressive symptoms.
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DOI：
10.1371/journal.pone.0114603
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Wei X;Shen H;Ren J;Li X;Xu X;Yang R;Lai L;Chen L;Hu J;Liu W;Jiang X
非临床抑郁症状（nCDS）的大脑基础在很大程度上尚不清楚。最近，用于分析静息态功能磁共振成像 (rs-fMRI) 数据的基于种子的功能连接 (FC) 方法已越来越多地用于探索抑郁症的神经基础。除了使用先验种子区域的常见基于种子的 FC 方法之外，我们还根据低频波动分数幅度 (fALFF) 方法揭示的自发活动改变的区域进行 FC 分析。本研究的目的是为大学生 nCDS 的潜在机制提供新的见解。共有 1105 名大学生被招募参加一项评估抑郁症状的调查。随后，17 名 nCDS 患者和 20 名健康对照 (HC) 被纳入进行 MR 研究。在右侧顶叶上小叶 (SPL) 和左侧舌回中发现了 fALFF 的变化，这两个区域都被用作进一步 FC 分析的 ROI。在右侧 SPL 中，与 HC 相比，nCDS 受试者的双侧背外侧前额叶皮层 (DLPFC)、左侧额下大师 (IFG)、左侧前运动皮层 (PMC)、DMN 网络 [即双侧楔前叶、后扣带皮层 (PCC)、右侧边缘上回] 的 FC 减少 （SMG），右侧海马旁回（PHG），双侧颞下上丘（ITG）]和左侧小脑后叶（CPL）。此外，在左侧舌回和右侧梭状回以及左侧楔前叶中观察到 FC 增加。我们的结果表明，右侧 SPL 和左侧舌回自发活动的异常及其相应的脑回路功能障碍可能与 nCDS 的病理生理学有关。
The underlying brain basis of nonclinical depressive symptoms (nCDSs) is largely unknown. Recently, the seed-based functional connectivity (FC) approach for analyzing resting-state fMRI (rs-fMRI) data has been increasingly used to explore the neural basis of depressive disorders. Other than common seed-based FC method using an a priori seed region, we conducted FC analysis based on regions with altered spontaneous activity revealed by the fractional amplitude of low-frequency fluctuations (fALFF) approach. The aim of the present study was to provide novel insight in the underlying mechanism of nCDSs in college students. A total number of 1105 college students were recruited to participant in a survey for assessing depressive symptoms. Subsequently, 17 individuals with nCDSs and 20 healthy controls (HCs) were enrolled to perform MR studies. Alternations of fALFF were identified in the right superior parietal lobule (SPL) and left lingual gyrus, both of which were used as ROIs for further FC analysis. With right SPL, compare with HCs, subjects with nCDSs showed reduced FCs in the bilateral dorsal lateral prefrontal cortex (DLPFC), left inferior frontal gurus (IFG), left premotor cortex (PMC), DMN network [i.e., bilateral precuneus, posterior cingulate cortex (PCC), right supramarginal gyrus (SMG), right parahippocampal gyrus (PHG), bilateral inferior temporal gurus (ITG)] and left cerebellum posterior lobe (CPL). In addition, increased FCs were observed between the left lingual gyrus and right fusiform gyrus as well as in the left precuneus. Our results indicate the abnormalities of spontaneous activity in the right SPL and left lingual gyrus and their corresponding dysfunction of the brain circuits might be related to the pathophysiology of nCDSs.
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DOI：
10.1176/appi.neuropsych.19.3.274
发表时间：
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影响因子：
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