Opioid receptor blockade and warmth-liking: effects on interpersonal trust and frontal asymmetry.

Opioid receptor blockade and warmth-liking: effects on interpersonal trust and frontal asymmetry.
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阿片受体阻断和温暖喜好:对人际信任和额叶不对称的影响

DOI:
10.1093/scan/nst152
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发表时间:
2014
影响因子:
4.2
通讯作者:
Wacker
Wacker
中科院分区:
医学3区
文献类型:
--
作者:
Schweiger;Stemmler;Burgdorf;Wacker

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与感情和接受感相关的“温暖-喜欢”情绪(WL)在社交环境中经常被激活。WL与目标实现后积极情感的完成阶段的关系比与目标实现前积极情感/接近动机的关系更密切,并且可能部分由脑阿片介导。为了验证这些假设,我们使用电影/图像来诱导女性参与者在摄入安慰剂或阿片类拮抗剂纳曲酮后的中性情绪状态或WL。因变量为情绪自我报告、人际信任(trust,即WL的行为指标)和额叶不对称(即接近动机/行为激活的脑电图指标)。我们发现安慰剂/WL组的参与者报告的WL多于安慰剂/中性组和纳曲酮组。此外,安慰剂组的TRUST增加,而纳曲酮组的TRUST没有增加,而中性对照组的TRUST则相反。因此,阿片阻断抑制甚至逆转了WL诱导对自我报告和行为水平的影响。此外,我们观察到WL组相对左额叶不对称性减少,与接近动机减少一致。总的来说,这些结果表明阿片能对WL和信任有影响,并降低了积极情绪WL的接近动机/行为激活。
The emotion ‘warmth-liking’ (WL) associated with feelings of affection and acceptance is regularly activated in social contexts. WL has been suggested to be more closely related to the consummatory phase of post-goal attainment positive affect than to pre-goal attainment positive affect/approach motivation and to be partly mediated by brain opioids. To validate these assumptions we employed film/imagery to induce either a neutral emotional state or WL in female participants after intake of either placebo or the opioid antagonist naltrexone. Dependent variables were emotion self-report, interpersonal trust (TRUST, i.e. a behavioral indicator of WL) and frontal asymmetry (i.e. an electroencephalogram (EEG) indicator of approach motivation/behavioral activation). We found that participants reported more WL in the placebo/WL group than in the placebo/neutral group and both naltrexone groups. In addition, TRUST increased in the WL group after placebo, but not after naltrexone, and this pattern was reversed in the neutral control groups. Consequently, opioid blockade suppressed or even reversed the effects of the WL induction on the levels of self-report and behavior, respectively. In addition, we observed reduced relative left-frontal asymmetry in the WL (vsneutral) group, consistent with reduced approach motivation. Overall, these results suggest opioidergic influences on WL and TRUST and reduced approach motivation/behavioral activation for the positive emotion WL.
DOI: 10.1037/1528-3542.8.2.232
发表时间: 2008
期刊: Emotion
影响因子: 4.2
作者:
Jan Wacker;Mira;A. Leue;G. Stemmler
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期刊: The Behavioral and brain sciences
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发表时间: 2009-06
期刊: EMOTION
影响因子: 4.2
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DOI: --
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期刊:
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