The Role and Therapeutic Implications of Inflammation in the Pathogenesis of Brain Arteriovenous Malformations.
The Role and Therapeutic Implications of Inflammation in the Pathogenesis of Brain Arteriovenous Malformations.
复制标题
炎症在脑动静脉畸形发病机制中的作用和治疗意义。
DOI：
10.3390/biomedicines11112876
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发表时间：
2023-10-24
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
脑动静脉畸形（bAVMs）是由异常血管通道组成的局灶性血管病变，无毛细血管网络介入。结果，高压动脉血直接分流到静脉流出系统。这些高流量、低阻力的分流由扩张、弯曲和脆弱的血管组成，这些血管容易破裂。bavm是儿童和年轻人出血性中风的主要原因。目前的治疗方法仅限于手术、栓塞和放射手术，尽管由于风险过高，这些方法对约20%的AVM患者也不可行。重要的是，炎症已被认为有助于病变进展。在此，我们总结了目前讨论免疫系统在脑血管瘤发病和病变进展中的作用的文献，以及靶向炎症预防脑血管瘤破裂和颅内出血的潜力。我们的结论是，功能失调的内皮细胞，其包含的体细胞突变已被证明可以引起散发性的bavm，可能通过改变大脑的免疫状态来驱动疾病的发展和进展。
Brain arteriovenous malformations (bAVMs) are focal vascular lesions composed of abnormal vascular channels without an intervening capillary network. As a result, high-pressure arterial blood shunts directly into the venous outflow system. These high-flow, low-resistance shunts are composed of dilated, tortuous, and fragile vessels, which are prone to rupture. BAVMs are a leading cause of hemorrhagic stroke in children and young adults. Current treatments for bAVMs are limited to surgery, embolization, and radiosurgery, although even these options are not viable for ~20% of AVM patients due to excessive risk. Critically, inflammation has been suggested to contribute to lesion progression. Here we summarize the current literature discussing the role of the immune system in bAVM pathogenesis and lesion progression, as well as the potential for targeting inflammation to prevent bAVM rupture and intracranial hemorrhage. We conclude by proposing that a dysfunctional endothelium, which harbors the somatic mutations that have been shown to give rise to sporadic bAVMs, may drive disease development and progression by altering the immune status of the brain.
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影响因子：
8.3
作者：
ApSimon, HT;Reef, H;Popovic, EA
通讯作者：
Popovic, EA
影响因子：
64.8
作者：
Ahn, Ji Hoon;Cho, Hyunsoo;Koh, Gou Young
通讯作者：
Koh, Gou Young
影响因子：
4.1
作者：
BROWN, RD;WIEBERS, DO;MACIUNAS, RJ
通讯作者：
MACIUNAS, RJ
影响因子：
6
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通讯作者：
Miller RH
影响因子：
5.5
作者：
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通讯作者：
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