Interference between competing motor memories developed through learning with different limbs.
Interference between competing motor memories developed through learning with different limbs.
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DOI：
10.1152/jn.00905.2017
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发表时间：
2018-09-01
影响因子：
2.5
通讯作者：
Mutha PK
中科院分区：
文献类型：
--
作者：
Kumar N;Kumar A;Sonane B;Mutha PK
从发生在不同肢体的运动错误中学习对于有效的工具使用、运动训练和康复是必不可少的。为了探索四肢错误驱动学习的神经组织，我们询问了用双臂学习相反的视觉运动映射是否会干扰。年轻的右撇子首先适应了不同手臂的相反的视觉运动旋转A和B，然后在24小时后再次暴露于A。我们观察到，如果没有b的干扰，则A的重新学习不会更快，初始误差也不会小于先前的A学习，相反，根据手臂学习的顺序，误差大于或类似于先前的A学习，并且学习率比先前的A学习慢或相当。这表明，当用不同的手臂连续学习A和B的运动记忆时，它们之间存在强烈的干扰。然后，我们进一步发现，重新暴露后的顺序依赖的表现不对称是由于学习从左臂到右臂的不对称转移，而不是相反，并且观察到的干扰本质上是逆行的。这种逆行干扰的发生可能是因为两只手臂需要相同的神经资源来学习，这与我们过去的研究一致，表明无论使用哪只手臂，左下顶叶损伤都会导致学习受损。因此，这些结果指出了不同肢体形成新运动记忆的共同神经基础，并对新形成的运动记忆如何相互作用具有重要意义。
Learning from motor errors that occur across different limbs is essential for effective tool use, sports training and rehabilitation. To probe the neural organization of error-driven learning across limbs, we asked whether learning opposing visuomotor mappings with the two arms would interfere. Young right-handers first adapted to opposite visuomotor rotations A and B with different arms, and were then re-exposed to A 24 hours later. We observed that re-learning of A was never faster, nor were initial errors smaller than prior A learning, which would be expected if there was no interference from B. Rather, errors were greater than or similar to, and learning rate was slower than or comparable to previous A learning depending on the order in which the arms learned. This indicated robust interference between the motor memories of A and B when they were learned with different arms in close succession. We then proceeded to uncover that the order-dependent asymmetry in performance upon re-exposure resulted from asymmetric transfer of learning from the left arm to the right but not vice-versa, and that the observed interference was retrograde in nature. Such retrograde interference likely occurs because the two arms require the same neural resources for learning, a suggestion consistent with that of our past work showing impaired learning following left inferior parietal damage regardless of the arm used. These results thus point to a common neural basis for formation of new motor memories with different limbs, and hold significant implications for how newly formed motor memories interact.
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影响因子：
3.7
作者：
Heuer, Herbert;Hegele, Mathias
通讯作者：
Hegele, Mathias
DOI：
10.1073/pnas.93.9.3843
发表时间：
1996-04-30
影响因子：
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作者：
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56.9
作者：
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影响因子：
2.5
作者：
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通讯作者：
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