Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring.
Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring.
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DOI：
10.1038/ijo.2013.12
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发表时间：
2013-11
影响因子：
4.9
通讯作者：
Gozal, D.
中科院分区：
文献类型：
--
作者：
Khalyfa, A.;Carreras, A.;Hakim, F.;Cunningham, J. M.;Wang, Y.;Gozal, D.
饮食变化等暴露于锗可通过表观遗传修饰改变后代的表型，并增加患代谢综合征等特定疾病的风险。我们假设，妊娠晚期高脂饮食（HFD）会通过组织脂肪细胞因子基因的相关表观遗传学改变导致胰岛素抵抗和高脂血症的风险增加。对在妊娠晚期（HFDO）喂食HFD的母亲的后代小鼠称重，并且每周测量其食物摄入量，直到20周龄，此时评估葡萄糖和胰岛素耐受性试验、血浆脂质和脂肪细胞因子水平以及内脏脂肪中的mRNA表达。内脏脂肪、肝脏和肌肉中的脂肪细胞因子基因甲基化水平也进行了测定。HFDO小鼠的体重增加和食物摄入增加，并表现出胰岛素抵抗、高脂血症、高瘦素血症以及低脂联素血症。此外，在HFDO小鼠中，脂联素和瘦素受体甲基化增加，瘦素基因甲基化降低，GLP-1甲基化模式不变。总之，妊娠晚期HFD诱导后代代谢综合征的风险增加，这与低脂联素血症以及瘦素抵抗相结合，并且伴随脂肪细胞因子基因中选择性的基于组织的表观遗传变化的存在。
Gestational exposures such as dietary changes can alter offspring phenotype through epigenetic modifications and promote increased risk for specific diseases, such as metabolic syndrome. We hypothesized that high fat diet (HFD) during late gestation would lead increased risk for insulin resistance and hyperlipidemia via associated epigenetic alterations in tissue adipocytokine genes. Offspring mice of mothers fed a HFD during late gestation (HFDO) were weighed and their food intake measured weekly till age 20 weeks at which time glucose and insulin tolerance tests, plasma lipid and adipocytokine levels were assessed, as well as mRNA expression in visceral fat. Adipocytokine gene methylation levels in visceral fat, liver, and muscle were also assayed. HFDO mice had increased weight accrual and food intake, and exhibited insulin resistance, hyperlipidemia, and hyperleptinemia, as well as hypoadiponectinemia. Furthermore, increased methylation of adiponectin and leptin receptor, and decreased methylation of leptin genes with unchanged GLP-1 methylation patterns emerged in HFDO mice. Taken together, late gestational HFD induces increased risk of metabolic syndrome in the progeny, which is coupled with hypoadiponectinemia as well as with leptin resistance, and concomitant presence of selective tissue-based epigenetic changes among adipocytokine genes.
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DOI：
10.1073/pnas.0705667104
发表时间：
2007-07-31
影响因子：
11.1
作者：
Gluckman, Peter D.;Lillycrop, Karen A.;Hanson, Mark A.
通讯作者：
Hanson, Mark A.
DOI：
10.1017/cbo9780511544699.003
发表时间：
2006-01-01
期刊：
DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
影响因子：
--
作者：
Godfrey, Keith
通讯作者：
Godfrey, Keith
影响因子：
9.8
作者：
Gregersen, S;Dyrskog, SEU;Hermansen, K
通讯作者：
Hermansen, K
影响因子：
8.9
作者：
Lihn, AS;Pedersen, SB;Richelsen, B
通讯作者：
Richelsen, B
影响因子：
3.7
作者：
Oberlander, Tim F.;Weinberg, Joanne;Devlin, Angela M.
通讯作者：
Devlin, Angela M.