Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study.
Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study.
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DOI：
10.3390/diagnostics10090723
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发表时间：
2020-09-20
期刊：
影响因子：
--
通讯作者：
Sorodoc L
中科院分区：
文献类型：
--
作者：
Ceasovschih A;Sorodoc V;Onofrei Aursulesei V;Tesloianu D;Tuchilus C;Anisie E;Petris A;Statescu C;Jaba E;Stoica A;Grigorescu ED;Jaba IM;Sorodoc L
外周动脉疾病（PAD）是全身性动脉粥样硬化的常见表现，全世界有超过2亿患者受到影响。目前，还没有理想的PAD风险分层和诊断的生物标志物。本研究的目的是调查炎症生物标志物和胱抑素C的水平，并探讨它们在PAD诊断中的应用。该研究包括296名参与者，分为两组：216名诊断为PAD的患者和80名未诊断为PAD的患者作为对照。所有研究的生物标志物水平（C反应蛋白、CRP、纤维蛋白原、红细胞沉降率、ESR、新蝶呤、β 2-微球蛋白、B2-MG和胱抑素C）在PAD组均显著升高，并与踝臂指数（ABI）间接相关。最终的逻辑回归模型包括新天鹅蛋白、纤维蛋白原和胱抑素C作为预测PAD诊断最有效的标志物的关联。当比较所有生物标记物的曲线下面积（AUC）时，新蝶呤的值显著高于所有其他分析的生物标记物。与以往的研究一致，本研究表明纤维蛋白原、CRP、ESR、B2-MG、胱抑素C等标志物对PAD的诊断具有重要价值，也清楚地强调了新蝶呤作为PAD预测的主要生物标志物的准确性。
Peripheral arterial disease (PAD) is a common manifestation of generalized atherosclerosis, which affects more than 200 million patients worldwide. Currently, there is no ideal biomarker for PAD risk stratification and diagnosis. The goal of this research was to investigate the levels of inflammation biomarkers and cystatin C and to explore their utility for the diagnosis of PAD. The study included 296 participants, distributed in two groups: 216 patients diagnosed with PAD and 80 patients without PAD as controls. All studied biomarker levels (C-reactive protein, CRP; fibrinogen; erythrocyte sedimentation rate, ESR; neopterin; beta 2-microglobulin, B2-MG; and cystatin C) were significantly higher in the PAD group and indirectly correlated with the ankle–brachial index (ABI). The final logistic regression model included an association of neopterin, fibrinogen, and cystatin C as the most efficient markers for the prediction of PAD diagnosis. When comparing the area under the curve (AUC) for all biomarkers, the value for neopterin was significantly higher than those of all the other analyzed biomarkers. In agreement with previous studies, this research shows that markers such as fibrinogen, CRP, ESR, B2-MG, and cystatin C have significant value for the diagnosis of PAD, and also clearly underlines the accuracy of neopterin as a leading biomarker in PAD prediction.
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DOI：
10.1007/s00772-017-0269-4
发表时间：
2017
期刊：
Gefasschirurgie : Zeitschrift fur vaskulare und endovaskulare Chirurgie : Organ der Deutschen und der Osterreichischen Gesellschaft fur Gefasschirurgie unter Mitarbeit der Schweizerischen Gesellschaft fur Gefasschirurgie
影响因子：
--
作者：
Harwood AE;Totty JP;Broadbent E;Smith GE;Chetter IC
通讯作者：
Chetter IC
影响因子：
5.3
作者：
Arpegard, J.;Oestergren, J.;Svensson, P.
通讯作者：
Svensson, P.
影响因子：
4.3
作者：
Alabi, Olamide;Roos, Matthew;Moneta, Gregory
通讯作者：
Moneta, Gregory
影响因子：
2.7
作者：
Harrison, Michael
通讯作者：
Harrison, Michael
影响因子：
4.3
作者：
Brevetti, G;Silvestro, A;Scopacasa, F
通讯作者：
Scopacasa, F