Time Course of Relapse Following Acute Treatment for Anorexia Nervosa.
Time Course of Relapse Following Acute Treatment for Anorexia Nervosa.
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DOI：
10.1176/appi.ajp.2021.21010026
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发表时间：
2021-09-01
期刊：
影响因子：
--
通讯作者：
Kaplan AS
中科院分区：
文献类型：
--
作者：
Walsh BT;Xu T;Wang Y;Attia E;Kaplan AS
There is long-standing interest in how best to define stages of illness for anorexia nervosa, including remission and recovery. The current analysis used data from a previously published study to examine the time course of relapse over the year following full weight restoration. Following weight restoration in an acute care setting, 93 women with anorexia nervosa were randomly assigned to receive fluoxetine or placebo, and were discharged to outpatient care where they also received cognitive behavioral therapy for up to one year. Relapse was defined on the basis of a priori clinical criteria. Fluoxetine had no impact on the time to relapse. In the current analysis, for each day after entry into the study, the risk of relapse over the following 60 days and the following 90 days was calculated and a parametric function was fitted to approximate the Kaplan-Meier estimator. The risk of relapse rose immediately after entry into the study, reached a peak after approximately 60 days, and then gradually fell. There was no indication of an inflection point at which the risk of relapse fell precipitously after the initial peak. The current analysis highlights that adult patients with anorexia nervosa are at increased risk of relapse in the first months following discharge from acute care, suggesting a need for frequent follow-up and relapse prevention-focused treatment during this period. After approximately two months, the risk of relapse progressively decreases over time.
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作者：
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