Characterization of New PEEK/HA Composites with 3D HA Network Fabricated by Extrusion Freeforming.
Characterization of New PEEK/HA Composites with 3D HA Network Fabricated by Extrusion Freeforming.
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DOI：
10.3390/molecules21060687
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发表时间：
2016-05-26
期刊：
影响因子：
--
通讯作者：
Yang S
中科院分区：
文献类型：
--
作者：
Vaezi M;Black C;Gibbs DM;Oreffo RO;Brady M;Moshrefi-Torbati M;Yang S
添加生物活性材料，如磷酸钙或生物玻璃，并将孔隙掺入聚醚醚酮（PEEK）中，已被确定为改善骨植入物界面和基于PEEK的设备骨整合的有效方法。本文提出了一种基于挤压自由成形方法的新型生产技术，该技术生产出具有生物活性的PEEK/羟基磷灰石（PEEK/HA）复合材料，该复合材料具有独特的结构，其中生物活性相（即HA）分布在PEEK基质内由计算机控制。生物复合材料中HA网络的100%互连性比其他微结构配置的替代形式具有优势。此外，该技术可用于生产孔径和分布可控的多孔PEEK结构，促进患者组织内更大的细胞浸润和PEEK复合材料的生物整合。在静态和循环模式下，对这些新的含40% HA的PEEK/HA生物复合材料进行无侧限单轴压缩测试的结果是有希望的，表明复合材料的屈服强度和抗压强度在适合承载应用的人类皮质骨的范围内。此外，本文还论证了支持新技术初步生物安全性的初步证据。充分的细胞附着，与样品接触超过7天的持续活力，细胞桥接和基质沉积的证据都证实了良好的生物相容性。
Addition of bioactive materials such as calcium phosphates or Bioglass, and incorporation of porosity into polyetheretherketone (PEEK) has been identified as an effective approach to improve bone-implant interfaces and osseointegration of PEEK-based devices. In this paper, a novel production technique based on the extrusion freeforming method is proposed that yields a bioactive PEEK/hydroxyapatite (PEEK/HA) composite with a unique configuration in which the bioactive phase (i.e., HA) distribution is computer-controlled within a PEEK matrix. The 100% interconnectivity of the HA network in the biocomposite confers an advantage over alternative forms of other microstructural configurations. Moreover, the technique can be employed to produce porous PEEK structures with controlled pore size and distribution, facilitating greater cellular infiltration and biological integration of PEEK composites within patient tissue. The results of unconfined, uniaxial compressive tests on these new PEEK/HA biocomposites with 40% HA under both static and cyclic mode were promising, showing the composites possess yield and compressive strength within the range of human cortical bone suitable for load bearing applications. In addition, preliminary evidence supporting initial biological safety of the new technique developed is demonstrated in this paper. Sufficient cell attachment, sustained viability in contact with the sample over a seven-day period, evidence of cell bridging and matrix deposition all confirmed excellent biocompatibility.
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影响因子：
8
作者：
Deng Y;Liu X;Xu A;Wang L;Luo Z;Zheng Y;Deng F;Wei J;Tang Z;Wei S
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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作者：
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