Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival.
Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival.
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DOI：
10.1038/s41598-022-12788-z
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发表时间：
2022-05-27
影响因子：
4.6
通讯作者：
Nead, Kevin T.
中科院分区：
文献类型：
--
作者：
Carey, Ryan M.;Kim, TaeBeom;Cohen, Noam A.;Lee, Robert J.;Nead, Kevin T.
甜味、鲜味和苦味的受体最初在舌头上被鉴定为具有化学感受作用，在一些癌症中表达，它们调节重要的细胞过程，包括细胞凋亡和增殖。我们使用癌症基因组图谱和基因型组织表达项目数据库，检测了45种实体瘤亚型与相应正常组织中编码甜味或鲜味受体（TAS 1 R）和苦味受体（TAS 2 R）的基因的DNA突变（n = 5103）、结构变异（n = 7545）和表达（n = 6224）。TAS 1 R和TAS 2 R基因的表达在正常组织和癌组织中不同，并且在许多实体瘤味觉受体基因中发生非沉默突变（~ 1-7%）。某些TAS 1 R/TAS 2 R的表达水平与12种实体瘤亚型的生存差异相关。TAS 1 R1表达的增加与肺腺癌生存期的改善相关（平均生存期差异+1185天，p = 0.0191）。TAS 2 R14表达增加与肾上腺皮质癌（-1757天，p < 0.001）和食管腺癌（-640天，p = 0.0041）的生存率降低相关，但非乳头状膀胱癌的生存率提高（+343天，p = 0.0436）。某些味觉受体基因可能与重要的肿瘤学途径相关，并可作为疾病结局的生物标志物。
Originally identified on the tongue for their chemosensory role, the receptors for sweet, umami, and bitter taste are expressed in some cancers where they regulate important cellular processes including apoptosis and proliferation. We examined DNA mutations (n = 5103), structural variation (n = 7545), and expression (n = 6224) of genes encoding sweet or umami receptors (TAS1Rs) and bitter receptors (TAS2Rs) in 45 solid tumors subtypes compared to corresponding normal tissue using The Cancer Genome Atlas and the Genotype Tissue Expression Project databases. Expression of TAS1R and TAS2R genes differed between normal and cancer tissue, and nonsilent mutations occurred in many solid tumor taste receptor genes (~ 1–7%). Expression levels of certain TAS1Rs/TAS2Rs were associated with survival differences in 12 solid tumor subtypes. Increased TAS1R1 expression was associated with improved survival in lung adenocarcinoma (mean survival difference + 1185 days, p = 0.0191). Increased TAS2R14 expression was associated with worse survival in adrenocortical carcinoma (−1757 days, p < 0.001) and esophageal adenocarcinoma (−640 days, p = 0.0041), but improved survival in non-papillary bladder cancer (+ 343 days, p = 0.0436). Certain taste receptor genes may be associated with important oncologic pathways and could serve as biomarkers for disease outcomes.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
4.8
作者：
Clark, Adam A.;Dotson, Cedrick D.;Munger, Steven D.
通讯作者：
Munger, Steven D.
影响因子：
4.6
作者：
Choi, Jeong-Hwa;Lee, Jeonghee;Kim, Jeongseon
通讯作者：
Kim, Jeongseon
影响因子：
3.1
作者：
Bachmanov AA;Bosak NP;Lin C;Matsumoto I;Ohmoto M;Reed DR;Nelson TM
通讯作者：
Nelson TM
TAS2R38基因多态性与大肠癌风险之间的关联：在两个独立的高加索起源人群中进行的病例对照研究。
影响因子：
3.7
作者：
Carrai M;Steinke V;Vodicka P;Pardini B;Rahner N;Holinski-Feder E;Morak M;Schackert HK;Görgens H;Stemmler S;Betz B;Kloor M;Engel C;Büttner R;Naccarati A;Vodickova L;Novotny J;Stein A;Hemminki K;Propping P;Försti A;Canzian F;Barale R;Campa D
通讯作者：
Campa D