Pregnancy Weight Gain by Gestational Age in Women with Uncomplicated Dichorionic Twin Pregnancies.

Pregnancy Weight Gain by Gestational Age in Women with Uncomplicated Dichorionic Twin Pregnancies.
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DOI:
10.1111/ppe.12446
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发表时间:
2018-03
影响因子:
2.8
通讯作者:
Bodnar LM
Bodnar LM
中科院分区:
医学3区
文献类型:
--
作者:
Hutcheon JA;Platt RW;Abrams B;Braxter BJ;Eckhardt CL;Himes KP;Bodnar LM

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双胎妊娠不良结局的风险增加,与单胎妊娠相比,与更大的妊娠期体重增加相关。需要进行研究,理清妊娠期、体重增加和不良结局之间的关系,为体重增加指南提供信息。我们绘制了双胎妊娠母亲胎龄体重增加的平均值、标准差和选择性比值的图表,并将其与单胎曲线进行比较。我们提取了在Magee-Womens医院(Pittsburgh,PA,1998-2013)分娩无并发症双胎妊娠的妇女的系列产前体重测量值,并将其与医院的围产期数据库合并。分层线性回归用于根据孕前BMI类别将妊娠体重增加表示为孕龄的平滑函数。创建了母体体重增加的平均值、标准差和平均值的周特异性值和天特异性值的图表。1109名妇女(573名正常体重,287名超重,249名肥胖)进行了产前体重测量(中位数:每名妇女11 [四分位数范围:9,13])。体重增加的斜率在正常体重的女性中最明显,并且随着孕前BMI的增加而变平(例如,正常体重、超重和肥胖女性在20周时的第50体重分别为6.8、5.7和3.6 kg,在37周时分别为19.8、18.1和14.4 kg)。17-19周后,双胞胎的体重增加模式与单胞胎不同。我们的图表为双胎妊娠中母亲体重增加的分类提供了一种工具。未来的工作需要确定与最佳妊娠健康结果相关的体重增加范围。
Twin pregnancies are at increased risk for adverse outcomes and are associated with greater gestational weight gain compared to singleton pregnancies. Studies that disentangle the relationship between gestational duration, weight gain and adverse outcomes are needed to inform weight gain guidelines. We created charts of the mean, standard deviation and select percentiles of maternal weight gain-for-gestational age in twin pregnancies and compared them to singleton curves. We abstracted serial prenatal weight measurements of women delivering uncomplicated twin pregnancies at Magee-Womens Hospital (Pittsburgh, PA, 1998–2013) and merged them with the hospital’s perinatal database. Hierarchical linear regression was used to express pregnancy weight gain as a smoothed function of gestational age according to pre-pregnancy BMI category. Charts of week- and day-specific values for the mean, standard deviation, and percentiles of maternal weight gain were created. Prenatal weight measurements (median: 11 [interquartile range: 9, 13] per woman) were available for 1109 women (573 normal weight, 287 overweight, and 249 obese). The slope of weight gain was most pronounced in normal weight women and flattened with increasing pre-pregnancy BMI (e.g., 50th percentiles of 6.8, 5.7, and 3.6 kg at 20 weeks and 19.8, 18.1, and 14.4 at 37 weeks in normal weight, overweight, and obese women, respectively). Weight gain patterns in twins diverged from singletons after 17–19 weeks. Our charts provide a tool for the classification of maternal weight gain in twin pregnancies. Future work is needed to identify the range of weight gain associated with optimal pregnancy health outcomes.
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