Social Network Plasticity of Mice Parental Behavior.
Social Network Plasticity of Mice Parental Behavior.
复制标题
DOI：
10.3389/fnins.2022.882850
复制
发表时间：
2022
影响因子：
4.3
通讯作者：
Orikasa, Chitose
中科院分区：
文献类型：
--
作者：
Orikasa, Chitose
关键词：
神经可塑性发生在发育阶段，对大脑的性别分化和随后的成人性别依赖行为变化至关重要。母性行为主要受到大脑中与性别相关的差异的影响;然而，即使是成熟的雄性小鼠，长期的社会隔离也会在第一次接触幼崽时诱发母性的检索和蹲下行为。社会环境影响成年人的固有行为并改变大脑中的分子结构，从而允许更高水平的相关基因表达和分子活性。这篇综述探讨了这样一种可能性，即尽管神经回路的发育与母性行为密切相关，但从神经分子的角度来看，成年人的大脑仍然可以保持其神经可塑性。此外，神经元机制，如神经递质和神经肽可能会影响社会行为的变化。本文还讨论了在母性行为的正性和负性作用模式中，调节养育和杀生（包括忽视行为）等行为的神经回路可能是通过下丘脑中的黑色素浓集激素（MCH）-催产素的神经中继来控制的。此外，MCH-催产素神经中继可能有助于对母性行为的抗焦虑作用，这与奖励回路有关。
Neural plasticity occurs during developmental stages and is essential for sexual differentiation of the brain and the ensuing sex-dependent behavioral changes in adults. Maternal behavior is primarily affected by sex-related differences in the brain; however, chronic social isolation even in mature male mice can induce maternal retrieving and crouching behavior when they are first exposed to pups. Social milieus influence the inherent behavior of adults and alter the molecular architecture in the brain, thereby allowing higher levels of associated gene expression and molecular activity. This review explores the possibility that although the development of neural circuits is closely associated with maternal behavior, the brain can still retain its neuroplasticity in adults from a neuromolecular perspective. In addition, neuronal machinery such as neurotransmitters and neuropeptides might influence sociobehavioral changes. This review also discusses that the neural circuits regulating behaviors such as parenting and infanticide (including neglect behavior), might be controlled by neural relay on melanin concentrating hormone (MCH)–oxytocin in the hypothalamus during the positive and negative mode of action in maternal behavior. Furthermore, MCH–oxytocin neural relay might contribute to the anxiolytic effect on maternal behavior, which is involved with reward circuits.
登录
查看更多内容
影响因子：
4.6
作者：
Almeida-Santos, Ana F.;Carvalho, Vinicius R.;Pereira, Grace S.
通讯作者：
Pereira, Grace S.
影响因子：
5.7
作者：
Danoff JS;Wroblewski KL;Graves AJ;Quinn GC;Perkeybile AM;Kenkel WM;Lillard TS;Parikh HI;Golino HF;Gregory SG;Carter CS;Bales KL;Connelly JJ
通讯作者：
Connelly JJ
影响因子：
5.3
作者：
Baroncelli, Laura;Scali, Manuela;Sale, Alessandro
通讯作者：
Sale, Alessandro
影响因子：
4.6
作者：
Choi K;Lee Y;Lee C;Hong S;Lee S;Kang SJ;Shin KS
通讯作者：
Shin KS
影响因子：
5.6
作者：
Alachkar, Amal;Alhassen, Lamees;Civelli, Olivier
通讯作者：
Civelli, Olivier